Results 91 to 100 of about 1,746 (180)

Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection

open access: yesHuman Vaccines & Immunotherapeutics, 2017
Staphylococcus aureus is the leading cause of nosocomial and community-acquired infections, including soft tissue and skin infections and bacteremia. However, efforts to develop an effective vaccine against S.
Brian L. Cheng   +8 more
doaj   +1 more source

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease

open access: yesmBio, 2016
Staphylococcus aureus produces numerous virulence factors, each contributing different mechanisms to bacterial pathogenesis in a spectrum of diseases. Alpha toxin (AT), a cytolytic pore-forming toxin, plays a key role in skin and soft tissue infections ...
C. Tkaczyk   +13 more
doaj   +1 more source

The role of humoral immunity and acute inflammation in protection against staphyloccocal dermonecrosis.

open access: greenImmunology, 1975
Mice were protected against the dermonecrotic effects of Staphylococcus aureus by previous infection with either coagulase-positive or coagulase-negative strains or by immunization with alpha-toxin. Passive protection was conferred by serum from previously infected mice or by alpha-antitoxin.
C S Easmon, A. A. Glynn
openalex   +3 more sources

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

open access: yesToxins, 2019
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make
Daniele Chaves-Moreira   +11 more
doaj   +1 more source

An expert-curated global database of online newspaper articles on spiders and spider bites [PDF]

open access: yes, 2022
Mass media plays an important role in the construction and circulation of risk perception associated with animals. Widely feared groups such as spiders frequently end up in the spotlight of traditional and social media.
al., et   +2 more
core   +1 more source

Extracellular matrix molecules as targets for brown spider venom toxins

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Loxoscelism, the term used to describe lesions and clinical manifestations induced by brown spider's venom (Loxosceles genus), has attracted much attention over the last years. Brown spider bites have been reported to cause a local and acute inflammatory
S.S. Veiga   +4 more
doaj   +1 more source

Inhibition of Virulence as Treatment Strategies for Staphylococcus aureus Infection [PDF]

open access: yes, 2015
Staphylococcus aureus is a global health threat due to its ability to cause significant morbidity and mortality and the exceptional capacity to acquire antibiotic resistance.
Daly, Seth Michael
core   +1 more source

Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis [PDF]

open access: yes, 2020
Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic infection, yet they lack expression of many virulence determinants associated with the pathogenicity of wild-type strains. We found that both wild-type S.
Acker, Karen P.   +11 more
core   +2 more sources

Scavenger Receptors: Promiscuous Players during Microbial Pathogenesis [PDF]

open access: yes, 2018
Innate immunity is the most broadly effective host defense, being essential to clear the majority of microbial infections. Scavenger Receptors comprise a family of sensors expressed in a multitude of host cells, whose dual role during microbial ...
Cabanes, D, Pombinho, R, Sousa, S
core   +1 more source

Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model [PDF]

open access: yes, 2017
published_or_final_versio
Cai, J   +11 more
core   +1 more source

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