Results 71 to 80 of about 1,183 (137)

Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA.

, 2000
The effectiveness of the chelating agent CaNa2EDTA and the peptidomimetic matrix metalloproteinase inhibitor batimastat (BB-94) to inhibit local tissue damage induced by Bothrops asper snake venom was studied in mice.
Rucavado Romero, Alexandra, G León, Y Cury, Ovadia, Michael, M Ovadia, León Montero, Guillermo, J M Gutiérrez, T Escalante, Franceschi, Aida, F Chaves, A Franceschi, Escalante Muñoz, Teresa, A Rucavado, Cury, Yara, Gutiérrez, José María, Chaves Mora, Fernando   +15 more
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Clinical and epidemiological features of definitive and presumed loxoscelism in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2002
A retrospective study analysed 359 proven or presume cases of loxoscelism seen at the Hospital Vital Brazil, Instituto Butantan, São Paulo, Brazil, between 1985 and 1996. The spider was identified in 14%.
Ceila Maria Sant'Ana MÁLAQUE, Jaime Enrique CASTRO-VALENCIA, João Luiz Costa CARDOSO, Francisco Oscar de Siqueira FRANÇA, Kátia Cristina BARBARO, Wen FAN Hui   +5 more
doaj  

Tetracycline Protects against Dermonecrosis Induced by Loxosceles Spider Venom [PDF]

, 2007
Envenomation by spiders belonging to the Loxosceles genus (brown spider) often results in local dermonecrotic lesions. We have previously shown that Loxosceles sphingomyelinase D (SMase D), the venom component responsible for all the pathological effects,
Tambourgi, Denise V., Fernandes-Pedrosa, Matheus de F., Gonçalves-de-Andrade, Rute M., Danielle Paixão-Cavalcante, Denise V. Tambourgi, Okamoto, Cinthya Kimori, Matheus de F. Fernandes-Pedrosa, Paixão-Cavalcante, Danielle, Carmen W. van den Berg, Rute M. Gonçalves-de-Andrade, Cinthya Kimori Okamoto, van den Berg, Carmen W.   +11 more
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Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags

BMC Genomics, 2008
Background The bite of spiders belonging to the genus Loxosceles can induce a variety of clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis, and persistent inflammation.
Almeida Diego D, Kobashi Leonardo S, Gonçalves-de-Andrade Rute M, Junqueira-de-Azevedo Inácio de LM, Fernandes-Pedrosa Matheus de F, Ho Paulo L, Tambourgi Denise V   +6 more
doaj   +1 more source

Loxoscelism: Case Report and Literature Review [PDF]

, 2014
La picadura de la araña del género Loxosceles produce dermonecrosis en el sitio de la lesión y complicaciones sistémicas secundarias a reacciones enzimáticas de su veneno, lo que aumenta la tasa de mortalidad.
Aguilar Martínez, Leonar; George Washington University, Salamanca Díaz, Natalia; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Segura Salguero, Juan Camilo; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Vargas Guerrero, Luis Alejandro; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio, Sarmiento Acuña, Karen; Pontificia Universidad Javeriana-Hospital Universitario San Ignacio   +4 more
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Active site mapping of Loxosceles phospholipases D: Biochemical and biological features

, 2016
Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure.
Brown, Joan Heller, Caruso, I., Nader, H. B. [UNIFESP], Vuitika, Larissa, Matsubara, F. H., Nader, Helena Bonciani [UNIFESP], Veiga, S. S., Takahashi, H. K. [UNIFESP], Toledo, M. S. [UNIFESP], Caruso, Icaro Putinhon, Senff-Ribeiro, Andrea, Toledo, M. S., Chaim, Olga Meiri, Coronado, Monika Aparecida, Coronado, M. A. [UNESP], Arni, Raghuvir Krishnaswamy, Lima, M. A. [UNIFESP], Coronado, M. A., Takahashi, Helio Kiyoshi [UNIFESP], Nader, H. B., Chaves-Moreira, Daniele, Vuitika, L., Chaim, O. M., Veiga, Silvio Sanches, Toledo, Marcos Sergio [UNIFESP], Caruso, I. [UNESP], Arni, R. K. [UNESP], Murakami, Mario Tyago, Murakami, M. T., Senff-Ribeiro, A., Arni, R. K. C, Lima, Marcelo Andrade [UNIFESP], Takahashi, H. K., Lima, M. A., Chaves-Moreira, D., Matsubara, Fernando Hitomi   +35 more
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Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: Endothelial cell membrane phospholipids as targets for toxicity [PDF]

, 2011
Brown spider dermonecrotic toxins (phospholipases-D) are the most well-characterized biochemical constituents of Loxosceles spp. venom. Recombinant forms are capable of reproducing most cutaneous and systemic manifestations such as dermonecrotic lesions,
Gremski, Waldemiro, Youssef B. Sade, Sade, Youssef B., Nader, Helena Bonciani [UNIFESP], Senff-Ribeiro, Andrea, Ferrer, Valéria P., Toledo, Marcos S., Silva, Dilza Trevisan, Ferrer, Valéria Pereira, Chaim, Olga M., Dilza Trevisan-Silva, Valéria P. Ferrer, Andrea Senff-Ribeiro, Gremski, Luiza H., Helena B. Nader, Hélio K. Takahashi, Nader, Helena B., Takahashi, Helio Kiyoshi [UNIFESP], Luiza H. Gremski, Trevisan-Silva, Dilza, Gremski, Luiza Helena [UNIFESP], Boia-Ferreira, Mariana, da Silveira, Rafael B., Toledo, Marcos Sergio [UNIFESP], Da Silveira, Rafael Bertoni, Olga M. Chaim, Veiga, Silvio Sanches [UNIFESP], Rafael B. da Silveira, Takahashi, Hélio K., Silvio S. Veiga, Chaim, Olga Meiri [UNIFESP], Mariana Bóia-Ferreira, Waldemiro Gremski, Marcos S. Toledo, Sade, Youssef Bacila, Veiga, Silvio S.   +35 more
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Deletion of agr or saeRS decreased virulence in a mouse model of skin infection.

, 2013
Mice were infected with 1×107 CFU of S. aureus strains 923, 923Δagr, or 923Δsae (n = 10–20 animals/group). (A) Deletion of agr or saeRS eliminated dermonecrosis, although abscesses still occured.
Christopher P. Montgomery (359170), Susan Boyle-Vavra (353230), Robert S. Daum (290833)   +2 more
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Loxoscelismo con síndrome compartimental agudo: reporte de un caso con desenlace exitoso

Revista Alergia México
Antecedentes: El loxoscelismo es un cuadro clínico tóxico provocado por la mordedura de arañas del género Loxosceles, con amplia distribución en todo el mundo.1 La fosfolipasa D es la responsable de la dermonecrosis, inflamación, agregación plaquetaria ...
Itzel Yoselin Sánchez-Pérez, Yareni Chávez- Ríos, Sergio Gerardo Moreno- Hernández, Andrea Velasco-Medina, Guillermo Velázquez-Sámano Velázquez-Samano, Espiridión Ramos-Martínez   +5 more
doaj   +1 more source

Envenomation by Loxosceles reclusa

, 1979
Envenomation by the brown recluse spider, Loxosceles reclusa, may result in a dermonecrosis which can be accompanied by systemic manifestations, including hemolytic anemia.
Norment, B. R., Foil, L. D.
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