Results 71 to 80 of about 952 (142)

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease

mBio, 2016
Staphylococcus aureus produces numerous virulence factors, each contributing different mechanisms to bacterial pathogenesis in a spectrum of diseases. Alpha toxin (AT), a cytolytic pore-forming toxin, plays a key role in skin and soft tissue infections ...
C. Tkaczyk, M. M. Hamilton, A. Sadowska, Y. Shi, C.S. Chang, P. Chowdhury, R. Buonapane, X. Xiao, P. Warrener, J. Mediavilla, B. Kreiswirth, J. Suzich, C. K. Stover, B. R. Sellman   +13 more
doaj   +1 more source

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

Toxins, 2019
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make
Daniele Chaves-Moreira, Fernando Hitomi Matsubara, Zelinda Schemczssen-Graeff, Elidiana De Bona, Vanessa Ribeiro Heidemann, Clara Guerra-Duarte, Luiza Helena Gremski, Carlos Chávez-Olórtegui, Andrea Senff-Ribeiro, Olga Meiri Chaim, Raghuvir Krishnaswamy Arni, Silvio Sanches Veiga   +11 more
doaj   +1 more source

Extracellular matrix molecules as targets for brown spider venom toxins

Brazilian Journal of Medical and Biological Research, 2001
Loxoscelism, the term used to describe lesions and clinical manifestations induced by brown spider's venom (Loxosceles genus), has attracted much attention over the last years. Brown spider bites have been reported to cause a local and acute inflammatory
S.S. Veiga, V.C. Zanetti, A. Braz, O.C. Mangili, W. Gremski   +4 more
doaj   +1 more source

Accidente por araña Loxosceles spp.: reporte de caso y revisión de literatura

Revista Universitas Medica, 2014
La picadura de la araña del género Loxosceles produce dermonecrosis en el sitio de la lesión y complicaciones sistémicas secundarias a reacciones enzimáticas de su veneno, lo que aumenta la tasa de mortalidad.
Leonar Aguiar Martínez, Pedro González, Karen Sarmiento Acuña, Natalia Salamanca Díaz, Juan Camilo Segura Salguero, Luis Alejandro Vargas Guerrero   +5 more
doaj  

Clinical and epidemiological features of definitive and presumed loxoscelism in São Paulo, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2002
A retrospective study analysed 359 proven or presume cases of loxoscelism seen at the Hospital Vital Brazil, Instituto Butantan, São Paulo, Brazil, between 1985 and 1996. The spider was identified in 14%.
Ceila Maria Sant'Ana MÁLAQUE, Jaime Enrique CASTRO-VALENCIA, João Luiz Costa CARDOSO, Francisco Oscar de Siqueira FRANÇA, Kátia Cristina BARBARO, Wen FAN Hui   +5 more
doaj  

Transcriptome analysis of Loxosceles laeta (Araneae, Sicariidae) spider venomous gland using expressed sequence tags

BMC Genomics, 2008
Background The bite of spiders belonging to the genus Loxosceles can induce a variety of clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis, and persistent inflammation.
Almeida Diego D, Kobashi Leonardo S, Gonçalves-de-Andrade Rute M, Junqueira-de-Azevedo Inácio de LM, Fernandes-Pedrosa Matheus de F, Ho Paulo L, Tambourgi Denise V   +6 more
doaj   +1 more source

Characteristics and Lethality of a Novel Recombinant  Dermonecrotic Venom Phospholipase D from  Hemiscorpius lepturus

Toxins, 2017
Hemoscorpius lepturus is the most medically important scorpion in Iran. The clinical signs of H. lepturus envenomation are remarkably similar to those reported for brown spiders, including dermonecrosis, hematuria, renal failure and even death.
Elham Torabi, Mahdi Behdani, Mohammad Hosseininejad Chafi, Reza Moazzami, Jean‐Marc Sabatier, Vahid Khalaj, Delavar Shahbazzadeh, Kamran Pooshang Bagheri   +7 more
doaj   +1 more source

Loxoscelismo con síndrome compartimental agudo: reporte de un caso con desenlace exitoso

Revista Alergia México
Antecedentes: El loxoscelismo es un cuadro clínico tóxico provocado por la mordedura de arañas del género Loxosceles, con amplia distribución en todo el mundo.1 La fosfolipasa D es la responsable de la dermonecrosis, inflamación, agregación plaquetaria ...
Itzel Yoselin Sánchez-Pérez, Yareni Chávez- Ríos, Sergio Gerardo Moreno- Hernández, Andrea Velasco-Medina, Guillermo Velázquez-Sámano Velázquez-Samano, Espiridión Ramos-Martínez   +5 more
doaj   +1 more source

Critical Assessment of the Prospects of Quorum-Quenching Therapy for Staphylococcus aureus Infection. [PDF]

Int J Mol Sci, 2023
Otto M.
europepmc   +1 more source

Kounis Syndrome: A Rare Case of Allergic Angina Secondary to Loxoscelism. [PDF]

Indian Dermatol Online J, 2023
Mohta A, Mohta A, Mohta A.
europepmc   +1 more source