Results 61 to 70 of about 952 (142)
Toxins, 2021 Bites by many Asiatic and African cobras (Genus: Naja) cause severe local dermonecrosis and myonecrosis, resulting in permanent disabilities. We studied the time scale in which two Indian polyvalent antivenoms, VINS and Bharat, remain capable of ...
Umesha Madhushani +4 more
doaj +1 more source
Brown Spider Venom Phospholipase-D Activity upon Different Lipid Substrates
Toxins, 2023 Brown spider envenomation results in dermonecrosis, characterized by an intense inflammatory reaction. The principal toxins of brown spider venoms are phospholipase-D isoforms, which interact with different cellular membrane components, degrade ...
Daniele Chaves-Moreira +9 more
doaj +1 more source
Artemia salina as an animal model for the preliminary evaluation of snake venom-induced toxicity
Toxicon: X, 2021 Lethality and cytotoxicity assays of snake venoms and their neutralization by antivenom require many mice for the experiments. Recent developments have prompted researchers to seek alternative strategies that minimize the use of mice in line with Russel ...
Mitchel Otieno Okumu +6 more
doaj +1 more source
Toxins, 2022 Bites of Loxosceles spiders can lead to a set of clinical manifestations called loxoscelism, and are considered a public health problem in many regions. The signs and symptoms of loxoscelism are divided into cutaneous and systemic forms.
Luiza Helena Gremski +7 more
doaj +1 more source
Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency [PDF]
Clinical and Vaccine Immunology, 2012 ABSTRACTStaphylococcus aureusalpha toxin (AT) is an important virulence determinant and may be a valid target for immunoprophylaxis against staphylococcal disease. Here we report the identification of potent inhibitory anti-AT monoclonal antibodies (MAbs) derived using B-cell hybridoma technology from VelocImmune mice engineered to produce IgG with a ...
C, Tkaczyk +11 more
openaire +2 more sources
mBio, 2018 Staphylococcus aureus is a major cause of morbidity and mortality worldwide. S. aureus colonizes 20 to 80% of humans at any one time and causes a variety of illnesses. Strains that are resistant to common antibiotics further complicate management.
Fan Zhang +5 more
doaj +1 more source
[Cutaneous loxoscelism in Portugal: a rare cause of dermonecrosis].
Acta medica portuguesa, 2016 Cutaneous loxoscelism is an exceptional diagnosis in Portugal, regardless of the documented presence of Loxosceles rufescens.We report a 33-year old female patient presenting to our clinic after having visualized a bite from a spider in the inner aspect of the right thigh.
Inês, Coutinho +5 more
openaire +1 more source
Anti-Alpha-Toxin Monoclonal Antibody and Antibiotic Combination Therapy Improves Disease Outcome and Accelerates Healing in a Staphylococcus aureus Dermonecrosis Model [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S.
Jamese J, Hilliard +13 more
openaire +2 more sources
Revista Brasileira em Promoção da Saúde, 2012 The loxoscelism is the most serious form of arachnidism in Brazil. The genus Loxosceles comprises more than 100 species of spiders in African and American continents. In Brazil, they are known as brown spiders.
Ricardo Marques Frezza
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2017 Staphylococcus aureus is the leading cause of nosocomial and community-acquired infections, including soft tissue and skin infections and bacteremia. However, efforts to develop an effective vaccine against S.
Brian L. Cheng +8 more
doaj +1 more source