Results 41 to 50 of about 1,746 (180)

Spider Bite Dermonecrosis: A Review of Loxoscelism

Journal of Surgery Research and Practice
Loxoscelism is the clinical condition caused by the bite of spiders belonging to the genus Loxosceles and is the only verified arachnological cause of dermonecrosis worldwide. More than 150 different species of this spider genus have been described, being Loxosceles laeta the only recognized cause of Loxoscelism in Chile.
Pedro Vidal GH
openalex   +2 more sources

The Health Status of Horses Used for at Least Six Complete Cycles of Loxoscelic Antivenom Production

Toxins, 2023
Antivenom production against Loxosceles venom relies on horses being immunized and bled for plasma harvest. One horse can partake in several cycles of antivenom production, which will require years of constant venom and adjuvant inoculation and bleeding.
Ana Luísa Soares de Miranda, Bruno Cesar Antunes, João Carlos Minozzo, Sabrina de Almeida Lima, Ana Flávia Machado Botelho, Marco Túlio Gomes Campos, Carlos Chávez-Olórtegui, Benito Soto-Blanco   +7 more
doaj   +1 more source

Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes

Frontiers in Microbiology, 2022
Engineered liposomes composed of the naturally occurring lipids sphingomyelin (Sm) and cholesterol (Ch) have been demonstrated to efficiently neutralize toxins secreted by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus.
Heidi Wolfmeier, Heidi Wolfmeier, Samuel J. T. Wardell, Leo T. Liu, Reza Falsafi, Annette Draeger, Eduard B. Babiychuk, Daniel Pletzer, Daniel Pletzer, Robert E. W. Hancock   +9 more
doaj   +1 more source

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +5 more sources

Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

FEBS Open Bio, Volume 11, Issue 12, Page 3262-3275, December 2021., 2021
The aim of this review is to discuss similarities and differences among the most explored bacterial enzymes that have both phospholipase C and sphingomyelinase C activities. The structural aspects of three of those enzymes, their substrate specificity, and in silico substrate docking analysis are discussed, as well as their mechanisms of toxicity in ...
Laura Monturiol‐Gross, Fabian Villalta‐Romero, Marietta Flores‐Díaz, Alberto Alape‐Girón   +3 more
wiley   +1 more source

Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom

Molecules, 2020
Hemiscorpius lepturus (H. lepturus) which belongs to the Scorpionidae family, is the deadliest scorpion in Iran. It causes pathological manifestations like dermonecrosis, hemolysis, renal failure, necrotic ulcers, and in some cases, even death. The venom
Abouzar Soleimani Moez, Reza H. Sajedi, Kamran Pooshang Bagheri, Jean-Marc Sabatier, Delavar Shahbazzadeh   +4 more
doaj   +1 more source

Diclofenac Resensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactams and Prevents Implant Infections

Advanced Science, Volume 8, Issue 13, July 7, 2021., 2021
Diclofenac enhances the sensitivity of methicillin‐resistant Staphylococcus aureus toward the β‐lactam antibiotics, which help to circumvent drug resistance and improve the antibacterial efficacy of conventional antibiotics. Besides, murine implant infection models show that diclofenac combined with oxacillin, can alleviate MRSA infections. Mechanistic
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue   +6 more
wiley   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination. [PDF]

Nat Commun
Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S.
Tomaszewski KL, Blanchard M, Olaniyi R, Brenton HR, Hayes S, Fatma F, Amarasinghe GK, Cho BK, Goo YA, DeDent AC, Fritz SA, Wardenburg JB.   +11 more
europepmc   +3 more sources