Results 41 to 50 of about 952 (142)

Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of <i>Loxosceles</i> Venom-Induced Dermonecrosis and Potential Therapeutic Targets. [PDF]

Int J Mol Sci
Dermonecrosis resulting from Loxosceles spider envenomation, primarily driven by the enzyme sphingomyelinase D (SMase D), is characterized by severe inflammation and nonhealing wounds. SMases can be classified as Class I or II based on their structural characteristics.
Pinto BF, Lopes PH, Trufen CEM, Ching Ching AT, Junqueira de Azevedo ILM, Nishiyama-Jr MY, de Souza MM, Pohl PC, Tambourgi DV.   +8 more
europepmc   +3 more sources

Histopathological characterization of experimentally induced cutaneous loxoscelism in rabbits inoculated with Loxosceles similis venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Envenomation by Loxosceles bites is characterized by dermonecrotic and/or systemic features that lead to several clinical signs and symptoms called loxoscelism. Dermonecrotic lesions are preceded by thrombosis of the dermal plexus.
NB Pereira, E Kalapothakis, AC Vasconcelos, M Chatzaki, LP Campos, FO Vieira, BLA Verçosa, SS Silva, WM Ferreira, L Moro   +9 more
doaj   +1 more source

Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates. [PDF]

PLoS ONE, 2013
Venoms of brown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans.
Daniel M Lajoie, Pamela A Zobel-Thropp, Vlad K Kumirov, Vahe Bandarian, Greta J Binford, Matthew H J Cordes   +5 more
doaj   +1 more source

Platelet participation in the pathogenesis of dermonecrosis induced by Loxosceles gaucho venom

Human & Experimental Toxicology, 2015
Loxosceles gaucho spider venom induces in vitro platelet activation and marked thrombocytopenia in rabbits. Herein, we investigated the involvement of platelets in the development of the dermonecrosis induced by L. gaucho venom, using thrombocytopenic rabbits as a model. L.
Tavares, F. L., Peichoto, María Elisa, Marcelino, J. R., Barbaro, K. C., Cirillo, M. C., Santoro, Marcelo Larami, Sano Martins, I. S.   +6 more
openaire   +3 more sources

Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis [PDF]

Scientific Reports, 2020
AbstractStaphylococcus aureus relies on quorum sensing to exert virulence to establish and maintain infection. Prior research demonstrated the potent quorum sensing inhibition effects of “430D-F5”, a refined extract derived from the fruits of Schinus terebinthifolia, a medicinal plant used for the traditional treatment of skin and soft tissue ...
Huaqiao Tang, Gina Porras, Morgan M. Brown, Francois Chassagne, James T. Lyles, John Bacsa, Alexander R. Horswill, Cassandra L. Quave   +7 more
openaire   +2 more sources

Loxoscelism: Cutaneous and Hematologic Manifestations

Advances in Hematology, Volume 2019, Issue 1, 2019., 2019
Background. Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of ...
Ngan Nguyen, Manjari Pandey, Lawrence Rice   +2 more
wiley   +1 more source

Sex‐Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Worldwide, an estimated 12 million people are infected with Leishmania spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses. Infection can remain asymptomatic or lead to a spectrum of diseases including cutaneous, mucocutaneous, and ...
Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez, Martin Holland   +3 more
wiley   +1 more source

Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Bothrops lanceolatus snake venom causes systemic thrombotic syndrome but also local inflammation involving extensive oedema, pain, and haemorrhage. Systemic thrombotic syndrome may lead to fatal pulmonary embolism and myocardial and cerebral infarction. Here, we investigated the ability of B.
Marie Delafontaine, Isadora Maria Villas-Boas, Giselle Pidde, Carmen W. van den Berg, Laurence Mathieu, Joël Blomet, Denise V. Tambourgi, Enrique Ortega   +7 more
wiley   +1 more source

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Evidence-Based Complementary and Alternative Medicine, Volume 2017, Issue 1, 2017., 2017
Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects.
Juliana Félix-Silva, Arnóbio Antônio Silva-Junior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa, Rainer W. Bussmann   +4 more
wiley   +1 more source

Reproductive Pathological Changes Associated with Experimental Subchronic Corynebacterium pseudotuberculosis Infection in Nonpregnant Boer Does

Journal of Pathogens, Volume 2016, Issue 1, 2016., 2016
Corynebacterium pseudotuberculosis causes caseous lymphadenitis (CLA), which is a contagious and chronic disease in sheep and goats. In order to assess the histopathological changes observed in the reproductive organs of nonpregnant does infected with the bacteria, 20 apparently healthy adult Boer does were divided into four inoculation groups ...
A. M. Othman, Y. Abba, F. F. A. Jesse, Y. M. Ilyasu, A. A. Saharee, A. W. Haron, M. Zamri-Saad, M. A. M. Lila, Hin-Chung Wong   +8 more
wiley   +1 more source