Results 41 to 50 of about 1,183 (137)

Loxoscelism: Cutaneous and Hematologic Manifestations

Advances in Hematology, Volume 2019, Issue 1, 2019., 2019
Background. Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of ...
Ngan Nguyen, Manjari Pandey, Lawrence Rice   +2 more
wiley   +1 more source

Sex‐Related Differences in Immune Response and Symptomatic Manifestations to Infection with Leishmania Species

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
Worldwide, an estimated 12 million people are infected with Leishmania spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses. Infection can remain asymptomatic or lead to a spectrum of diseases including cutaneous, mucocutaneous, and ...
Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodríguez, Martin Holland   +3 more
wiley   +1 more source

High throughput drug discovery towards novel therapeutics for snakebite dermonecrosis

, 2023
Snakebite envenomation is a neglected tropical disease that kills over 100,000 people per year and injures more than 400,000. Brazil suffers more than 26,000 snakebites per year.
Tuersley, Joseph
core   +1 more source

Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Bothrops lanceolatus snake venom causes systemic thrombotic syndrome but also local inflammation involving extensive oedema, pain, and haemorrhage. Systemic thrombotic syndrome may lead to fatal pulmonary embolism and myocardial and cerebral infarction. Here, we investigated the ability of B.
Marie Delafontaine, Isadora Maria Villas-Boas, Giselle Pidde, Carmen W. van den Berg, Laurence Mathieu, Joël Blomet, Denise V. Tambourgi, Enrique Ortega   +7 more
wiley   +1 more source

Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence

Evidence-Based Complementary and Alternative Medicine, Volume 2017, Issue 1, 2017., 2017
Snakebites are a serious problem in public health due to their high morbimortality. Most of snake venoms produce intense local tissue damage, which could lead to temporary or permanent disability in victims. The available specific treatment is the antivenom serum therapy, whose effectiveness is reduced against these effects.
Juliana Félix-Silva, Arnóbio Antônio Silva-Junior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa, Rainer W. Bussmann   +4 more
wiley   +1 more source

The calcium-dependent protease of Loxosceles gaucho venom acts preferentially upon red cell band 3 transmembrane protein

Brazilian Journal of Medical and Biological Research, 2003
Eighty micrograms red blood cell (RBC) ghosts from patients who had previously exhibited the cutaneous form of loxoscelism (presenting localized dermonecrosis) and the viscerocutaneous form of loxoscelism (presenting dermonecrosis, hemoglobinuria ...
O.C. de O. Barretto, M. Satake, K. Nonoyama, J.L.C. Cardoso   +3 more
doaj   +1 more source

Reproductive Pathological Changes Associated with Experimental Subchronic Corynebacterium pseudotuberculosis Infection in Nonpregnant Boer Does

Journal of Pathogens, Volume 2016, Issue 1, 2016., 2016
Corynebacterium pseudotuberculosis causes caseous lymphadenitis (CLA), which is a contagious and chronic disease in sheep and goats. In order to assess the histopathological changes observed in the reproductive organs of nonpregnant does infected with the bacteria, 20 apparently healthy adult Boer does were divided into four inoculation groups ...
A. M. Othman, Y. Abba, F. F. A. Jesse, Y. M. Ilyasu, A. A. Saharee, A. W. Haron, M. Zamri-Saad, M. A. M. Lila, Hin-Chung Wong   +8 more
wiley   +1 more source

Biochemical and Functional Characterization of Parawixia bistriata Spider Venom with Potential Proteolytic and Larvicidal Activities

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Toxins purified from the venom of spiders have high potential to be studied pharmacologically and biochemically. These biomolecules may have biotechnological and therapeutic applications. This study aimed to evaluate the protein content of Parawixia bistriata venom and functionally characterize its proteins that have potential for biotechnological ...
Gizeli S. Gimenez, Antonio Coutinho-Neto, Anderson M. Kayano, Rodrigo Simões-Silva, Frances Trindade, Alexandre de Almeida e Silva, Silvana Marcussi, Saulo L. da Silva, Carla F. C. Fernandes, Juliana P. Zuliani, Leonardo A. Calderon, Andreimar M. Soares, Rodrigo G. Stábeli, Edward G. Rowan   +13 more
wiley   +1 more source

Polymeric Nanoparticles for the Diagnosis and Treatment of Snakebite

Macromolecular Chemistry and Physics, Volume 227, Issue 1, 15 January 2026.
Snakebite envenomation affects between 1.8 and 5.5 million people annually, many of whom suffer disabilities or even death. Current antivenoms are composed of plasma‐derived antibodies. However, there remains an underexplored opportunity to utilise polymer‐based nanoparticles.
Neil Prabhakar, Thomas Oliver, Alexander N. Baker   +2 more
wiley   +1 more source

Alkylation of Histidine Residues of Bothrops jararacussu Venom Proteins and Isolated Phospholipases A2: A Biotechnological Tool to Improve the Production of Antibodies

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Crude venom of Bothrops jararacussu and isolated phospholipases A2 (PLA2) of this toxin (BthTX‐I and BthTX‐II) were chemically modified (alkylation) by p‐bromophenacyl bromide (BPB) in order to study antibody production capacity in function of the structure‐function relationship of these substances (crude venom and PLA2 native and alkylated).
C. L. S. Guimarães, S. H. Andrião-Escarso, L. S. Moreira-Dill, B. M. A. Carvalho, D. P. Marchi-Salvador, N. A. Santos-Filho, C. A. H. Fernandes, M. R. M. Fontes, J. R. Giglio, B. Barraviera, J. P. Zuliani, C. F. C. Fernandes, L. A. Calderón, R. G. Stábeli, F. Albericio, S. L. da Silva, A. M. Soares, Edward G. Rowan   +17 more
wiley   +1 more source