Results 21 to 30 of about 952 (142)
Frontiers in Veterinary Science, 2022 Loxosceles spp. (brown spiders) bites are responsible for the development of a syndrome consisting mainly of dermonecrotic lesions, and also systemic effects.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Clinical Effects of the Immunization Protocol Using Loxosceles Venom in Naïve Horses
Toxins, 2022 Bites of brown spiders (Loxosceles spp.) are responsible for dermonecrotic lesions and potentially systemic envenoming that can lead to death. The only effective therapy is the use of the antivenom, usually produced in horses.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
An oral caspase inhibitor as monotherapy or with antibiotics eradicates MRSA skin infections in mice
Drug Development Research, Volume 84, Issue 8, Page 1567-1571, December 2023., 2023 Abstract Staphylococcus aureus is the leading cause of skin and soft tissue infections. With the emergence of antibiotic‐resistant bacteria, there is an unmet clinical need to develop immune‐based therapies to treat skin infections. Previously, we have shown pan‐caspase inhibition as a potential host‐directed immunotherapy against community‐acquired ...
Emily Cahill +6 more
wiley +1 more source
South African Medical Journal, 2022 Wound infections following cytotoxic snakebites are common. Bites from Naja nigricincta nigricincta (an African spitting cobra) usually present as severe dermonecrosis spreading within the subdermal fascia layer.
EL Saaiman, PJ (Christo) Buys
doaj +1 more source
The Health Status of Horses Used for at Least Six Complete Cycles of Loxoscelic Antivenom Production
Toxins, 2023 Antivenom production against Loxosceles venom relies on horses being immunized and bled for plasma harvest. One horse can partake in several cycles of antivenom production, which will require years of constant venom and adjuvant inoculation and bleeding.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes
Frontiers in Microbiology, 2022 Engineered liposomes composed of the naturally occurring lipids sphingomyelin (Sm) and cholesterol (Ch) have been demonstrated to efficiently neutralize toxins secreted by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus.
Heidi Wolfmeier +9 more
doaj +1 more source
Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva +15 more
wiley +1 more source
Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
FEBS Open Bio, Volume 11, Issue 12, Page 3262-3275, December 2021., 2021 The aim of this review is to discuss similarities and differences among the most explored bacterial enzymes that have both phospholipase C and sphingomyelinase C activities. The structural aspects of three of those enzymes, their substrate specificity, and in silico substrate docking analysis are discussed, as well as their mechanisms of toxicity in ...
Laura Monturiol‐Gross +3 more
wiley +1 more source
Advanced Science, Volume 8, Issue 13, July 7, 2021., 2021 Diclofenac enhances the sensitivity of methicillin‐resistant Staphylococcus aureus toward the β‐lactam antibiotics, which help to circumvent drug resistance and improve the antibacterial efficacy of conventional antibiotics. Besides, murine implant infection models show that diclofenac combined with oxacillin, can alleviate MRSA infections. Mechanistic
Shutao Zhang +6 more
wiley +1 more source
Local Cytotoxic Effects in Cobra Envenoming: A Pilot Study
Toxins, 2022 The cobra (genus Naja (N.)) is one of the most common venomous snakes. Due to its frequency and deadly complications of muscle paralysis, local necrosis, and chronic musculoskeletal disability, it should not be ignored.
Jing-Hua Lin +3 more
doaj +1 more source