Results 21 to 30 of about 1,183 (137)
A Male with Acute Dermonecrosis over the Right Flank [PDF]
Indian Dermatology Online JournalVijayasankar Palaniappan +2 more
doaj +2 more sources
Angewandte Chemie, Volume 134, Issue 24, June 13, 2022., 2022 A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.
Korbin H. J. West +8 more
wiley +2 more sources
Clinical Effects of the Immunization Protocol Using Loxosceles Venom in Naïve Horses
Toxins, 2022 Bites of brown spiders (Loxosceles spp.) are responsible for dermonecrotic lesions and potentially systemic envenoming that can lead to death. The only effective therapy is the use of the antivenom, usually produced in horses.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Frontiers in Veterinary Science, 2022 Loxosceles spp. (brown spiders) bites are responsible for the development of a syndrome consisting mainly of dermonecrotic lesions, and also systemic effects.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
An oral caspase inhibitor as monotherapy or with antibiotics eradicates MRSA skin infections in mice
Drug Development Research, Volume 84, Issue 8, Page 1567-1571, December 2023., 2023 Abstract Staphylococcus aureus is the leading cause of skin and soft tissue infections. With the emergence of antibiotic‐resistant bacteria, there is an unmet clinical need to develop immune‐based therapies to treat skin infections. Previously, we have shown pan‐caspase inhibition as a potential host‐directed immunotherapy against community‐acquired ...
Emily Cahill +6 more
wiley +1 more source
The Health Status of Horses Used for at Least Six Complete Cycles of Loxoscelic Antivenom Production
Toxins, 2023 Antivenom production against Loxosceles venom relies on horses being immunized and bled for plasma harvest. One horse can partake in several cycles of antivenom production, which will require years of constant venom and adjuvant inoculation and bleeding.
Ana Luísa Soares de Miranda +7 more
doaj +1 more source
Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of <i>Loxosceles</i> Venom-Induced Dermonecrosis and Potential Therapeutic Targets. [PDF]
Int J Mol SciDermonecrosis resulting from Loxosceles spider envenomation, primarily driven by the enzyme sphingomyelinase D (SMase D), is characterized by severe inflammation and nonhealing wounds.
Pinto BF +8 more
europepmc +2 more sources
Targeting the Pseudomonas aeruginosa Virulence Factor Phospholipase C With Engineered Liposomes
Frontiers in Microbiology, 2022 Engineered liposomes composed of the naturally occurring lipids sphingomyelin (Sm) and cholesterol (Ch) have been demonstrated to efficiently neutralize toxins secreted by Gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus.
Heidi Wolfmeier +9 more
doaj +1 more source
Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva +15 more
wiley +1 more source
Molecules, 2020 Hemiscorpius lepturus (H. lepturus) which belongs to the Scorpionidae family, is the deadliest scorpion in Iran. It causes pathological manifestations like dermonecrosis, hemolysis, renal failure, necrotic ulcers, and in some cases, even death. The venom
Abouzar Soleimani Moez +4 more
doaj +1 more source