Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL [PDF]
Scientific Reports, 2023 Snakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world.
Timothy P Jenkins
exaly +10 more sources
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms [PDF]
Nature Communications, 2023 Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven Hall +2 more
exaly +10 more sources
Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation [PDF]
Revista Da Sociedade Brasileira De Medicina Tropical, 2022 Background: Although loxoscelism (bites by brown spiders of the genus Loxosceles) frequently results in dermonecrosis, no previous clinical reports have provided detailed temporal photodocumentation of the evolution of dermonecrotic lesions in a case ...
Eduardo Mello de Capitani +2 more
exaly +5 more sources
Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis [PDF]
PLoS ONE, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Rute Maria Gonçalves-De-Andrade +2 more
exaly +4 more sources
Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin [PDF]
EBioMedicine, 2018 Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), typified by the pulse-field type USA300, is an emerging endemic pathogen that is spreading rapidly among healthy people.
Robert D Hancock +2 more
exaly +6 more sources
Toxins, 2017 Hemorrhage is the most prominent effect of snake venom metalloproteinases (SVMPs) in human envenomation. The capillary injury is a multifactorial effect caused by hydrolysis of the components of the basement membrane (BM).
Solange M T Serrano +2 more
exaly +4 more sources
Brown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications [PDF]
ToxinsAccidents caused by Loxosceles spiders, commonly known as brown spiders, are frequent in warm and temperate regions worldwide, with a higher prevalence in South America and the southern United States.
Ana Carolina Martins Wille +7 more
doaj +3 more sources
Protective effects of mesenchymal stromal cell-derived secretome on dermonecrosis induced in rabbits by Loxosceles intermedia spider venom [PDF]
Journal of Venomous Animals and Toxins Including Tropical DiseasesBackground: Loxoscelism refers to a set of clinical manifestations caused by the bite of spiders from the Loxosceles genus. The classic clinical symptoms are characterized by an intense inflammatory reaction at the bite site followed by local necrosis ...
Carlos Chavéz-Olortegui, Marilia Melo
exaly +4 more sources
STUDIES ON PYOCIN TYPING, DERMONECROSIS AND PATHOGENICITY OF E.COLI RECOVERED FROM SEPTICAEMIC BROILER CHICKENS [PDF]
Veterinary Medical Journal (Jizah, Egypt: 1995), 1995 E..coli was recovered from 59.00% of septicaemic broiler chickens suffering enteritis, perihepatitis and airsacculitis. Pyocin typing of chosen E. coli jsolates revealed two types. The first type was able to grow in the presence of pyocin (PREC).
A El-Gohary
exaly +2 more sources
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poorly ...
Jaffer Alsolaiss +7 more
doaj +2 more sources