Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL [PDF]
Scientific Reports, 2023 Snakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world.
Keirah E Bartlett +2 more
exaly +7 more sources
Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation [PDF]
Revista Da Sociedade Brasileira De Medicina Tropical, 2022 Background: Although loxoscelism (bites by brown spiders of the genus Loxosceles) frequently results in dermonecrosis, no previous clinical reports have provided detailed temporal photodocumentation of the evolution of dermonecrotic lesions in a case ...
Camila Carbone Prado +2 more
exaly +9 more sources
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms [PDF]
Nature Communications, 2023 Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms.
Steven R Hall +2 more
exaly +7 more sources
Protective effects of mesenchymal stromal cell-derived secretome on dermonecrosis induced in rabbits by Loxosceles intermedia spider venom [PDF]
Journal of Venomous Animals and Toxins Including Tropical DiseasesBackground: Loxoscelism refers to a set of clinical manifestations caused by the bite of spiders from the Loxosceles genus. The classic clinical symptoms are characterized by an intense inflammatory reaction at the bite site followed by local necrosis ...
CARLOS Chavéz-Olortegui +2 more
exaly +7 more sources
Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis [PDF]
PLoS ONE, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Correa +2 more
exaly +5 more sources
Effects of copaiba oil on dermonecrosis induced by Loxosceles intermedia venom [PDF]
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2019 Background: Accidents caused by spiders of the genus Loxosceles constitute an important public health problem in Brazil. The venom of Loxosceles sp induces dermonecrosis at the bite site and systemic disease in severe cases. Traditional medicine based on
Mara Fernandes Ribeiro +1 more
exaly +6 more sources
Insights into the Mechanisms Involved in Strong Hemorrhage and Dermonecrosis Induced by Atroxlysin-Ia, a PI-Class Snake Venom Metalloproteinase [PDF]
Toxins, 2017 Hemorrhage is the most prominent effect of snake venom metalloproteinases (SVMPs) in human envenomation. The capillary injury is a multifactorial effect caused by hydrolysis of the components of the basement membrane (BM).
Luciana A Freitas-De-Sousa +2 more
exaly +5 more sources
Investigating Snake-Venom-Induced Dermonecrosis and Inflammation Using an Ex Vivo Human Skin Model [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease that causes >100,000 deaths and >400,000 cases of morbidity annually. Despite the use of mouse models, severe local envenoming, defined by morbidity-causing local tissue necrosis, remains poorly ...
Jaffer Alsolaiss +7 more
doaj +4 more sources
A Male with Acute Dermonecrosis over the Right Flank [PDF]
Indian Dermatology Online JournalVijayasankar Palaniappan +2 more
doaj +4 more sources
Brown Spider Venom Phospholipases D: From Potent Molecules Involved in Pathogenesis of Brown Spider Bites to Molecular Tools for Studying Ectosomes, Ectocytosis, and Its Applications [PDF]
ToxinsAccidents caused by Loxosceles spiders, commonly known as brown spiders, are frequent in warm and temperate regions worldwide, with a higher prevalence in South America and the southern United States.
Ana Carolina Martins Wille +7 more
doaj +2 more sources