Results 11 to 20 of about 1,746 (180)

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis. [PDF]

PLoS Neglected Tropical Diseases, 2018
Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective
Jeffrey O'Brien, Shih-Hui Lee, José María Gutiérrez, Kenneth J Shea   +3 more
doaj   +7 more sources

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model. [PDF]

PLoS ONE, 2013
An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation.
Christine Tkaczyk, Melissa M Hamilton, Vivekananda Datta, Xiang Ping Yang, Jamese J Hilliard, Geoffrey L Stephens, Agnieszka Sadowska, Lei Hua, Terrence O'Day, JoAnn Suzich, Charles Kendall Stover, Bret R Sellman   +11 more
doaj   +5 more sources

Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, Nicholas R. Casewell   +3 more
doaj   +6 more sources

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib [PDF]

Proceedings of the National Academy of Sciences, 2023
AbstractSnakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ineffectively treated by current antivenoms.
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu L, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR.   +13 more
europepmc   +6 more sources

Loxosceles Sphingomyelinase Induces Complement-Dependent Dermonecrosis, Neutrophil Infiltration, and Endogenous Gelatinase Expression [PDF]

Journal of Investigative Dermatology, 2005
Envenomation by the spider Loxosceles can result in dermonecrosis and severe ulceration. Our aim was to investigate the role of the complement system and of the endogenous metalloproteinases in the initiation of the pathology of dermonecrosis. Histological analysis of skin of rabbits injected with Loxosceles intermedia venom and purified or recombinant
Denise V Tambourgi, Danielle Paixão-Cavalcante, Matheus de Freitas Fernandes-Pedrosa   +2 more
exaly   +4 more sources

Local Dermonecrosis with Generalized Urticaria Probably Due to Loxosceles rufescens Bite [PDF]

Open Access Macedonian Journal of Medical Sciences, 2020
BACKGROUND: The spiders of the Loxosceles genus, commonly denoted as “brown spiders” or “Mediterranean recluse” or “brown recluse,” belong to the spider family Sicariidae, suborder Labidognatha, order Araneida, class Arachnida, and phylum Arthropoda ...
Ioannis Alexandros Charitos, Leonardo Pennisi, Anna Lepore, Luigì Santacroce   +3 more
core   +8 more sources

Differential Cellular Responses to Class I and II Sphingomyelinase D: Unraveling the Mechanisms of <i>Loxosceles</i> Venom-Induced Dermonecrosis and Potential Therapeutic Targets. [PDF]

Int J Mol Sci
Dermonecrosis resulting from Loxosceles spider envenomation, primarily driven by the enzyme sphingomyelinase D (SMase D), is characterized by severe inflammation and nonhealing wounds. SMases can be classified as Class I or II based on their structural characteristics.
Pinto BF, Lopes PH, Trufen CEM, Ching Ching AT, Junqueira de Azevedo ILM, Nishiyama-Jr MY, de Souza MM, Pohl PC, Tambourgi DV.   +8 more
europepmc   +5 more sources

α-Hemolysin-mediated endothelial injury contributes to the development of Staphylococcus aureus-induced dermonecrosis. [PDF]

Infect Immun
ABSTRACT Staphylococcus aureus α-hemolysin (Hla) is a pore-forming toxin critical for the pathogenesis of skin and soft tissue infections, which causes the pathognomonic lesion of cutaneous necrosis (dermonecrosis) in mouse models.
Yang C, Robledo-Avila FH, Partida-Sanchez S, Montgomery CP.   +3 more
europepmc   +5 more sources

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice

Toxicon, 2016
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection of venom induced a macroscopic necrotic lesion. Histological examination revealed early edema of the dermis, followed by blistering, loss of skin appendages and reduction in cellularity. By 24 h,
Mariángela Vargas, Guillermo Leon, Jose M Gutierrez   +2 more
exaly   +7 more sources

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. [PDF]

Proc Natl Acad Sci U S A
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ...
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR.   +13 more
europepmc   +11 more sources