Results 11 to 20 of about 1,183 (137)

Effects of copaiba oil on dermonecrosis induced by Loxosceles intermedia venom

Journal of Venomous Animals and Toxins Including Tropical Diseases, 2019
Background: Accidents caused by spiders of the genus Loxosceles constitute an important public health problem in Brazil. The venom of Loxosceles sp induces dermonecrosis at the bite site and systemic disease in severe cases. Traditional medicine based on
Felipe Leite de Oliveira, Mara Ribeiro
exaly   +4 more sources

A Murine Skin Infection Model Capable of Differentiating the Dermatopathology of Community-Associated MRSA Strain USA300 from Other MRSA Strains

Microorganisms, 2021
USA300 is a predominant and highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain that is a leading cause of skin and soft tissue infections.
Jack Zhang, John Conly, JoAnn McClure, Kaiyu Wu, Bjӧrn Petri, Duane Barber, Sameer Elsayed, Glen Armstrong, Kunyan Zhang   +8 more
doaj   +2 more sources

Fatal infective necrotising fasciitis: Complication following Naja nigricincta nigricincta bite (western barred spitting cobra/zebra snake) [PDF]

South African Medical Journal, 2022
Wound infections following cytotoxic snakebites are common. Bites from Naja nigricincta nigricincta (an African spitting cobra) usually present as severe dermonecrosis spreading within the subdermal fascia layer.
EL Saaiman, PJ (Christo) Buys
doaj   +2 more sources

Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper

Mediators of Inflammation, 2002
Envenomations by the snake Bothrops asper are characterized by prominent local tissue damage (i.e. myonecrosis), blistering, hemorrhage and edema. Various phospholipases A2 and metalloproteinases that induce local pathological alterations have been ...
Alexandra Rucavado, Teresa Escalante, Catarina F. P. Teixeira, Cristina María Fernándes, Cecilia Díaz, José María Gutiérrez   +5 more
doaj   +2 more sources

Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy [PDF]

Toxins, 2022
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to about 40 to 60% of the cobra venom proteome, play a significant role in cobra
Bhargab Kalita, Yuri N. Utkin, Ashis K. Mukherjee   +2 more
doaj   +2 more sources

Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes [PDF]

Toxins
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, Nicholas R. Casewell   +3 more
doaj   +2 more sources

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib. [PDF]

Proc Natl Acad Sci U S A
Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ...
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu LO, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR.   +13 more
europepmc   +7 more sources

A biofilm-targeting lipo-peptoid to treat Pseudomonas aeruginosa and Staphylococcus aureus co-infections [PDF]

Biofilm
Antibiotic-resistant bacterial infections are a significant clinical challenge, especially when involving multiple species. Antimicrobial peptides and their synthetic analogues, peptoids, which target bacterial cell membranes as well as intracellular ...
Samuel J.T. Wardell, Deborah B.Y. Yung, Josefine E. Nielsen, Rajesh Lamichhane, Kristian Sørensen, Natalia Molchanova, Claudine Herlan, Jennifer S. Lin, Stefan Bräse, Lyn M. Wise, Annelise E. Barron, Daniel Pletzer   +11 more
doaj   +2 more sources

LAIR1 prevents excess inflammatory tissue damage in Staphylococcus aureus skin infection and cutaneous T cell lymphoma [PDF]

JCI Insight
Patients with cutaneous T cell lymphoma (CTCL) experience high morbidity and mortality due to S. aureus skin infections and sepsis, but the underlying mechanisms remain unclear.
Hannah K. Dorando, Evan C. Mutic, Kelly L. Tomaszewski, Yulia Korshunova, Ling Tian, Mellisa K. Stefanov, Chaz C. Quinn, Deborah J. Veis, Juliane Bubeck Wardenburg, Amy C. Musiek, Neha Mehta-Shah, Jacqueline E. Payton   +11 more
doaj   +2 more sources

Accidente por araña Loxosceles spp.: reporte de caso y revisión de literatura

Revista Universitas Medica, 2014
La picadura de la araña del género Loxosceles produce dermonecrosis en el sitio de la lesión y complicaciones sistémicas secundarias a reacciones enzimáticas de su veneno, lo que aumenta la tasa de mortalidad.
Leonar Aguiar Martínez, Pedro González, Karen Sarmiento Acuña, Natalia Salamanca Díaz, Juan Camilo Segura Salguero, Luis Alejandro Vargas Guerrero   +5 more
doaj   +1 more source