Results 11 to 20 of about 952 (142)
Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis. [PDF]
PLoS Neglected Tropical Diseases, 2018 Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective
Jeffrey O'Brien +3 more
doaj +6 more sources
EBioMedicine, 2018 Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), typified by the pulse-field type USA300, is an emerging endemic pathogen that is spreading rapidly among healthy people.
Heidi Wolfmeier +2 more
exaly +3 more sources
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model. [PDF]
PLoS ONE, 2013 An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation.
Christine Tkaczyk +11 more
doaj +4 more sources
Current Insights in the Mechanisms of Cobra Venom Cytotoxins and Their Complexes in Inducing Toxicity: Implications in Antivenom Therapy [PDF]
Toxins, 2022 Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to about 40 to 60% of the cobra venom proteome, play a significant role in cobra
Bhargab Kalita +2 more
doaj +2 more sources
STUDIES ON PYOCIN TYPING, DERMONECROSIS AND PATHOGENICITY OF E.COLI RECOVERED FROM SEPTICAEMIC BROILER CHICKENS [PDF]
Veterinary Medical Journal - Giza, 1995 E..coli was recovered from 59.00% of septicaemic broiler chickens suffering enteritis, perihepatitis and airsacculitis. Pyocin typing of chosen E. coli jsolates revealed two types. The first type was able to grow in the presence of pyocin (PREC).
A EL-GOHARY, G ABD El-GABER
doaj +2 more sources
Mediators of Inflammation, 2002 Envenomations by the snake Bothrops asper are characterized by prominent local tissue damage (i.e. myonecrosis), blistering, hemorrhage and edema. Various phospholipases A2 and metalloproteinases that induce local pathological alterations have been ...
Alexandra Rucavado +5 more
doaj +2 more sources
Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes [PDF]
ToxinsSnakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Keirah E. Bartlett +3 more
doaj +2 more sources
A biofilm-targeting lipo-peptoid to treat Pseudomonas aeruginosa and Staphylococcus aureus co-infections [PDF]
BiofilmAntibiotic-resistant bacterial infections are a significant clinical challenge, especially when involving multiple species. Antimicrobial peptides and their synthetic analogues, peptoids, which target bacterial cell membranes as well as intracellular ...
Samuel J.T. Wardell +11 more
doaj +2 more sources
Angewandte Chemie, Volume 134, Issue 24, June 13, 2022., 2022 A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.
Korbin H. J. West +8 more
wiley +2 more sources
Microorganisms, 2021 USA300 is a predominant and highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain that is a leading cause of skin and soft tissue infections.
Jack Zhang +8 more
doaj +1 more source