Results 31 to 40 of about 952 (142)

Rare case of dermonecrosis caused by a recluse spider bite in Europe [PDF]

BMJ Case Reports, 2016
Spider poisoning is rare in Europe, with very few reported cases in the literature. Recluse spider (genus Loxosceles) bites may lead to cutaneous and systemic manifestations known as loxoscelism. We report the second known case of spider bite poisoning in Malta caused by Loxosceles rufescens (Mediterranean recluse spider).
Monique, Cachia, Liam, Mercieca, Charles, Mallia Azzopardi, Michael J, Boffa   +3 more
openaire   +2 more sources

Tetracycline Protects against Dermonecrosis Induced by Loxosceles Spider Venom [PDF]

Journal of Investigative Dermatology, 2007
Envenomation by spiders belonging to the Loxosceles genus (brown spider) often results in local dermonecrotic lesions. We have previously shown that Loxosceles sphingomyelinase D (SMase D), the venom component responsible for all the pathological effects, induced the expression of matrix metalloproteinases (MMPs) in rabbits and in human keratinocytic ...
Paixão-Cavalcante, Danielle, van den Berg, Carmen W., Gonçalves-de-Andrade, Rute M., Fernandes-Pedrosa, Matheus de F., Okamoto, Cinthya Kimori, Tambourgi, Denise V.   +5 more
openaire   +2 more sources

Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom

Molecules, 2020
Hemiscorpius lepturus (H. lepturus) which belongs to the Scorpionidae family, is the deadliest scorpion in Iran. It causes pathological manifestations like dermonecrosis, hemolysis, renal failure, necrotic ulcers, and in some cases, even death. The venom
Abouzar Soleimani Moez, Reza H. Sajedi, Kamran Pooshang Bagheri, Jean-Marc Sabatier, Delavar Shahbazzadeh   +4 more
doaj   +1 more source

α-Hemolysin-mediated endothelial injury contributes to the development of Staphylococcus aureus-induced dermonecrosis. [PDF]

Infect Immun
ABSTRACT Staphylococcus aureus α-hemolysin (Hla) is a pore-forming toxin critical for the pathogenesis of skin and soft tissue infections, which causes the pathognomonic lesion of cutaneous necrosis (dermonecrosis) in mouse models.
Yang C, Robledo-Avila FH, Partida-Sanchez S, Montgomery CP.   +3 more
europepmc   +3 more sources

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib [PDF]

Proceedings of the National Academy of Sciences, 2023
Abstract Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The venom of African spitting cobras often causes permanent injury via tissue-destructive dermonecrosis at the bite site, which is ineffectively treated by current antivenoms.
Bartlett KE, Hall SR, Rasmussen SA, Crittenden E, Dawson CA, Albulescu L, Laprade W, Harrison RA, Saviola AJ, Modahl CM, Jenkins TP, Wilkinson MC, Gutiérrez JM, Casewell NR.   +13 more
europepmc   +3 more sources

Verified envenomations by crevice weaver spiders (genus Kukulcania): Bites are of minor expression but the spiders are commonly misidentified as medically important brown recluses (genus Loxosceles) in North America

Toxicon: X, 2022
From southern North America, five verified bites by crevice weaver spiders, Kukulcania spp. (Filistatidae), are presented here, three of which are pediatric cases. Although the envenomation manifestations were of minimal expression, the salient aspect of
Richard S. Vetter
doaj   +1 more source

Insights into brown spider and loxoscelism [PDF]

Invertebrate Survival Journal, 2005
Loxosceles is a genus of cosmopolitan spiders comprising several species, and popularly known as brown spiders or brown recluses. Brown spider bites can cause dermonecrotic lesions and systemic reactions known as loxoscelism.
M H Appel, R Bertoni da Silveira, W Gremski, S S Veiga   +3 more
doaj   +1 more source

Acute kidney injury and dermonecrosis after Loxosceles reclusa envenomation

Indian Journal of Nephrology, 2014
Spiders of the Loxosceles species can cause dermonecrosis and acute kidney injury (AKI). Hemolysis, rhabdomyolysis and direct toxin-mediated renal damage have been postulated. There are very few reports of Loxoscelism from India. We report a case of AKI, hemolysis and a "gravitational" pattern of ulceration following the bite of the brown recluse ...
Nag, A., Datta, J., Das, A., Agarwal, A. K., Sinha, D., Mondal, S., Ete, T., Chakraborty, A., Ghosh, S.   +8 more
openaire   +2 more sources

Local Dermonecrosis with Generalized Urticaria Probably Due to Loxosceles rufescens Bite

Open Access Macedonian Journal of Medical Sciences, 2020
BACKGROUND: The spiders of the Loxosceles genus, commonly denoted as “brown spiders” or “Mediterranean recluse” or “brown recluse,” belong to the spider family Sicariidae, suborder Labidognatha, order Araneida, class Arachnida, and phylum Arthropoda.
Charitos, Ioannis Alexandros, Pennisi, Leonardo, Lepore, Anna, Santacroce, Luigi   +3 more
openaire   +3 more sources

Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin. [PDF]

PLoS ONE, 2015
The plethora of virulence factors associated with Staphylococcus aureus make this bacterium an attractive candidate for a molecularly-designed epitope-focused vaccine.
Jon Oscherwitz, Kemp B Cease
doaj   +1 more source