Results 31 to 40 of about 1,183 (137)
Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
FEBS Open Bio, Volume 11, Issue 12, Page 3262-3275, December 2021., 2021 The aim of this review is to discuss similarities and differences among the most explored bacterial enzymes that have both phospholipase C and sphingomyelinase C activities. The structural aspects of three of those enzymes, their substrate specificity, and in silico substrate docking analysis are discussed, as well as their mechanisms of toxicity in ...
Laura Monturiol‐Gross +3 more
wiley +1 more source
Local Cytotoxic Effects in Cobra Envenoming: A Pilot Study
Toxins, 2022 The cobra (genus Naja (N.)) is one of the most common venomous snakes. Due to its frequency and deadly complications of muscle paralysis, local necrosis, and chronic musculoskeletal disability, it should not be ignored.
Jing-Hua Lin +3 more
doaj +1 more source
Advanced Science, Volume 8, Issue 13, July 7, 2021., 2021 Diclofenac enhances the sensitivity of methicillin‐resistant Staphylococcus aureus toward the β‐lactam antibiotics, which help to circumvent drug resistance and improve the antibacterial efficacy of conventional antibiotics. Besides, murine implant infection models show that diclofenac combined with oxacillin, can alleviate MRSA infections. Mechanistic
Shutao Zhang +6 more
wiley +1 more source
Insights into brown spider and loxoscelism [PDF]
Invertebrate Survival Journal, 2005 Loxosceles is a genus of cosmopolitan spiders comprising several species, and popularly known as brown spiders or brown recluses. Brown spider bites can cause dermonecrotic lesions and systemic reactions known as loxoscelism.
M H Appel +3 more
doaj +1 more source
Toxicon: X, 2022 From southern North America, five verified bites by crevice weaver spiders, Kukulcania spp. (Filistatidae), are presented here, three of which are pediatric cases. Although the envenomation manifestations were of minimal expression, the salient aspect of
Richard S. Vetter
doaj +1 more source
Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin. [PDF]
PLoS ONE, 2015 The plethora of virulence factors associated with Staphylococcus aureus make this bacterium an attractive candidate for a molecularly-designed epitope-focused vaccine.
Jon Oscherwitz, Kemp B Cease
doaj +1 more source
Loxosceles Sphingomyelinase Induces Complement-Dependent Dermonecrosis, Neutrophil Infiltration, and Endogenous Gelatinase Expression [PDF]
, 2005 Envenomation by the spider Loxosceles can result in dermonecrosis and severe ulceration. Our aim was to investigate the role of the complement system and of the endogenous metalloproteinases in the initiation of the pathology of dermonecrosis ...
Tambourgi, Denise V. +13 more
core +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2012 Envenomation by Loxosceles bites is characterized by dermonecrotic and/or systemic features that lead to several clinical signs and symptoms called loxoscelism. Dermonecrotic lesions are preceded by thrombosis of the dermal plexus.
NB Pereira +9 more
doaj +1 more source
Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates. [PDF]
PLoS ONE, 2013 Venoms of brown spiders in the genus Loxosceles contain phospholipase D enzyme toxins that can cause severe dermonecrosis and even death in humans.
Daniel M Lajoie +5 more
doaj +1 more source
Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis. [PDF]
PLoS Neglected Tropical Diseases, 2018 Envenomings by snakebites constitute a serious and challenging global health issue. The mainstay in the therapy of snakebite envenomings is the parenteral administration of animal-derived antivenoms. Significantly, antivenoms are only partially effective
Jeffrey O'Brien +3 more
doaj +1 more source