Results 31 to 40 of about 1,746 (180)

CD36 Is Essential for Regulation of the Host Innate Response to Staphylococcus aureus α-Toxin–Mediated Dermonecrosis [PDF]

The Journal of Immunology, 2015
Abstract Staphylococcus aureus is the primary cause of skin and skin structure infections (SSSIs) in the United States. α-Hemolysin (Hla), a pore-forming toxin secreted by S. aureus and a major contributor to tissue necrosis, prompts recruitment of neutrophils critical for host defense against S. aureus infections.
Moriah J. Castleman, Maria Febbraio, Pamela R. Hall   +2 more
openalex   +3 more sources

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models [PDF]

Scientific Reports, 2017
AbstractWidespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues ...
Amelia Muhs, James T. Lyles, Corey P. Parlet, Kate Nelson, Jeffery S. Kavanaugh, Alexander R. Horswill, Cassandra L. Quave   +6 more
openalex   +3 more sources

Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment [PDF]

Journal of Investigative Dermatology, 2020
The staphylococcal α-hemolysin is critical for the pathogenesis of Staphylococcus aureus skin and soft tissue infection. Vaccine and infection-elicited α-hemolysin-specific antibodies protect against S. aureus‒induced dermonecrosis, a key feature of skin and soft tissue infection.
Ching Yang, Juan de Dios Ruiz‐Rosado, Frank Robledo‐Avila, Zhaotao Li, Ryan Jennings, Santiago Partida‐Sánchez, Christopher P. Montgomery   +6 more
openalex   +3 more sources

Sustained Release of a Synthetic Autoinducing Peptide Mimetic Blocks Bacterial Communication and Virulence In Vivo.

Angewandte Chemie, Volume 134, Issue 24, June 13, 2022., 2022
A synthetic peptide was found to block cell‐to‐cell signalling, or quorum sensing, in bacteria and be highly bioavailable in mouse tissue. The controlled release of this agent from degradable polymeric microparticles strongly inhibited skin infection in a wound model at levels that far surpassed the potency of the peptide when delivered conventionally.
Korbin H. J. West, Curran G. Gahan, Patricia R. Kierski, Diego F. Calderon, Ke Zhao, Charles J. Czuprynski, Jonathan F. McAnulty, David M. Lynn, Helen E. Blackwell   +8 more
wiley   +2 more sources

A Murine Skin Infection Model Capable of Differentiating the Dermatopathology of Community-Associated MRSA Strain USA300 from Other MRSA Strains

Microorganisms, 2021
USA300 is a predominant and highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strain that is a leading cause of skin and soft tissue infections.
Jack Zhang, John Conly, JoAnn McClure, Kaiyu Wu, Bjӧrn Petri, Duane Barber, Sameer Elsayed, Glen Armstrong, Kunyan Zhang   +8 more
doaj   +1 more source

Protective Effectiveness of an Immunization Protocol Against the Toxic Effects of Loxosceles intermedia Venom in Rabbits

Frontiers in Veterinary Science, 2022
Loxosceles spp. (brown spiders) bites are responsible for the development of a syndrome consisting mainly of dermonecrotic lesions, and also systemic effects.
Ana Luísa Soares de Miranda, Sabrina de Almeida Lima, Ana Flávia Machado Botelho, Marco Túlio Gomes Campos, Camila Eckstein, João Carlos Minozzo, Carlos Delfin Chávez-Olórtegui, Benito Soto-Blanco   +7 more
doaj   +1 more source

A single amino acid substitution in Fibronectin Binding protein A (FnBPA) governs Staphylococcus aureus virulence via host transglutaminase-mediated fibrin crosslinking. [PDF]

PLoS Pathog
Staphylococcus aureus is an opportunistic pathogen that can cause different types of infections, ranging from skin lesions to life threatening diseases.
Motta C, Turley M, Barbieri G, Famà A, Coppolino F, Bellan Menegussi E, Geoghegan JA, Beninati C, Pellegrini A, Pietrocola G.   +9 more
europepmc   +3 more sources

Clinical Effects of the Immunization Protocol Using Loxosceles Venom in Naïve Horses

Toxins, 2022
Bites of brown spiders (Loxosceles spp.) are responsible for dermonecrotic lesions and potentially systemic envenoming that can lead to death. The only effective therapy is the use of the antivenom, usually produced in horses.
Ana Luísa Soares de Miranda, Bruno Cesar Antunes, João Carlos Minozzo, Sabrina de Almeida Lima, Ana Flávia Machado Botelho, Marco Túlio Gomes Campos, Carlos Delfin Chávez-Olórtegui, Benito Soto-Blanco   +7 more
doaj   +1 more source

An oral caspase inhibitor as monotherapy or with antibiotics eradicates MRSA skin infections in mice

Drug Development Research, Volume 84, Issue 8, Page 1567-1571, December 2023., 2023
Abstract Staphylococcus aureus is the leading cause of skin and soft tissue infections. With the emergence of antibiotic‐resistant bacteria, there is an unmet clinical need to develop immune‐based therapies to treat skin infections. Previously, we have shown pan‐caspase inhibition as a potential host‐directed immunotherapy against community‐acquired ...
Emily Cahill, Olusola O. Oladipo, Dustin Dikeman, Denion Prifti, Steven J. Mento, Lloyd S. Miller, Martin P. Alphonse   +6 more
wiley   +1 more source

Fatal infective necrotising fasciitis: Complication following Naja nigricincta nigricincta bite (western barred spitting cobra/zebra snake)

South African Medical Journal, 2022
Wound infections following cytotoxic snakebites are common. Bites from Naja nigricincta nigricincta (an African spitting cobra) usually present as severe dermonecrosis spreading within the subdermal fascia layer.
EL Saaiman, PJ (Christo) Buys
doaj   +1 more source