Results 51 to 60 of about 952 (142)

The calcium-dependent protease of Loxosceles gaucho venom acts preferentially upon red cell band 3 transmembrane protein

Brazilian Journal of Medical and Biological Research, 2003
Eighty micrograms red blood cell (RBC) ghosts from patients who had previously exhibited the cutaneous form of loxoscelism (presenting localized dermonecrosis) and the viscerocutaneous form of loxoscelism (presenting dermonecrosis, hemoglobinuria ...
O.C. de O. Barretto, M. Satake, K. Nonoyama, J.L.C. Cardoso   +3 more
doaj   +1 more source

Biochemical and Functional Characterization of Parawixia bistriata Spider Venom with Potential Proteolytic and Larvicidal Activities

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Toxins purified from the venom of spiders have high potential to be studied pharmacologically and biochemically. These biomolecules may have biotechnological and therapeutic applications. This study aimed to evaluate the protein content of Parawixia bistriata venom and functionally characterize its proteins that have potential for biotechnological ...
Gizeli S. Gimenez, Antonio Coutinho-Neto, Anderson M. Kayano, Rodrigo Simões-Silva, Frances Trindade, Alexandre de Almeida e Silva, Silvana Marcussi, Saulo L. da Silva, Carla F. C. Fernandes, Juliana P. Zuliani, Leonardo A. Calderon, Andreimar M. Soares, Rodrigo G. Stábeli, Edward G. Rowan   +13 more
wiley   +1 more source

Alkylation of Histidine Residues of Bothrops jararacussu Venom Proteins and Isolated Phospholipases A2: A Biotechnological Tool to Improve the Production of Antibodies

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Crude venom of Bothrops jararacussu and isolated phospholipases A2 (PLA2) of this toxin (BthTX‐I and BthTX‐II) were chemically modified (alkylation) by p‐bromophenacyl bromide (BPB) in order to study antibody production capacity in function of the structure‐function relationship of these substances (crude venom and PLA2 native and alkylated).
C. L. S. Guimarães, S. H. Andrião-Escarso, L. S. Moreira-Dill, B. M. A. Carvalho, D. P. Marchi-Salvador, N. A. Santos-Filho, C. A. H. Fernandes, M. R. M. Fontes, J. R. Giglio, B. Barraviera, J. P. Zuliani, C. F. C. Fernandes, L. A. Calderón, R. G. Stábeli, F. Albericio, S. L. da Silva, A. M. Soares, Edward G. Rowan   +17 more
wiley   +1 more source

Unwanted disorders and xenogeneic graft‐versus‐host disease in experimental immunodeficient mice: How to evaluate and how to report

Animal Models and Experimental Medicine, Volume 8, Issue 1, Page 20-29, January 2025.
Xenograft‐bearing immunodeficient mice are susceptible to developing unwanted disorders primarily irrelevant to nature of the xenografted tumor; and if get involved with such disorders, they do not produce reliable results, inevitably confounding the research outputs.
Seyed Mostafa Monzavi, Samad Muhammadnejad, Vahid Mansouri, Hami Ashraf, Naser Ahmadbeigi   +4 more
wiley   +1 more source

Biochemical Characterization, Action on Macrophages, and Superoxide Anion Production of Four Basic Phospholipases A2 from Panamanian Bothrops asper Snake Venom

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Bothrops asper (Squamata: Viperidae) is the most important venomous snake in Central America, being responsible for the majority of snakebite accidents. Four basic PLA2s (pMTX‐I to ‐IV) were purified from crude venom by a single‐step chromatography using a CM‐Sepharose ion‐exchange column (1.5 × 15 cm).
Aristides Quintero Rueda, Isela González Rodríguez, Eliane C. Arantes, Sulamita S. Setúbal, Leonardo de A. Calderon, Juliana P. Zuliani, Rodrigo G. Stábeli, Andreimar M. Soares, Luis A. Ponce Soto   +8 more
wiley   +1 more source

Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models [PDF]

Scientific Reports, 2017
AbstractWidespread antibiotic resistance is on the rise and current therapies are becoming increasingly limited in both scope and efficacy. Methicillin-resistant Staphylococcus aureus (MRSA) represents a major contributor to this trend. Quorum sensing controlled virulence factors include secreted toxins responsible for extensive damage to host tissues ...
Amelia Muhs, James T. Lyles, Corey P. Parlet, Kate Nelson, Jeffery S. Kavanaugh, Alexander R. Horswill, Cassandra L. Quave   +6 more
openaire   +2 more sources

Highlights in the knowledge of brown spider toxins

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function.
Daniele Chaves-Moreira, Andrea Senff-Ribeiro, Ana Carolina Martins Wille, Luiza Helena Gremski, Olga Meiri Chaim, Silvio Sanches Veiga   +5 more
doaj   +1 more source

Prospecting Local Treatments Used in Conjunction with Antivenom Administration Following Envenomation Caused by Animals: A Systematic Review

Toxins, 2023
Envenomation caused by venomous animals may trigger significant local complications such as pain, edema, localized hemorrhage, and tissue necrosis, in addition to complications such as dermonecrosis, myonecrosis, and even amputations.
Érica S. Carvalho, Isadora Oliveira, Thaís P. Nascimento, Alexandre Vilhena da Silva Neto, Brenda A. S. Leal, Felipe Q. Araújo, Bruno F. V. Julião, Andrea R. N. Souza, Andreza W. Abrahim, Bruna B. O. Macedo, Jéssica T. S. de Oliveira, Fan Hui Wen, Manuela B. Pucca, Wuelton M. Monteiro, Jacqueline A. G. Sachett   +14 more
doaj   +1 more source

Feasibility of using a combination of staphylococcal superantigen‐like proteins 3, 7 and 11 in a fusion vaccine for Staphylococcus aureus

Immunology &Cell Biology, Volume 102, Issue 5, Page 365-380, May‐June 2024.
This study demonstrates that three secreted immune evasion factors from the staphylococcal superantigen‐like (SSL) protein family—SSL3, 7 and 11—can be successfully fused into a polyprotein. Mice immunized with a functionally inactive version of the polyprotein in the squalene‐based adjuvant (AddaVax), but not the equivalent amount of the individual ...
Janlin Ying Hui Chan, Fiona Clow, Victoria Pearson, Ries J Langley, John D Fraser, Fiona J Radcliff   +5 more
wiley   +1 more source

CD36 Is Essential for Regulation of the Host Innate Response to Staphylococcus aureus α-Toxin–Mediated Dermonecrosis [PDF]

The Journal of Immunology, 2015
Abstract Staphylococcus aureus is the primary cause of skin and skin structure infections (SSSIs) in the United States. α-Hemolysin (Hla), a pore-forming toxin secreted by S. aureus and a major contributor to tissue necrosis, prompts recruitment of neutrophils critical for host defense against S. aureus infections.
Moriah J, Castleman, Maria, Febbraio, Pamela R, Hall   +2 more
openaire   +2 more sources