Results 51 to 60 of about 1,746 (180)

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Insights into brown spider and loxoscelism [PDF]

Invertebrate Survival Journal, 2005
Loxosceles is a genus of cosmopolitan spiders comprising several species, and popularly known as brown spiders or brown recluses. Brown spider bites can cause dermonecrotic lesions and systemic reactions known as loxoscelism.
M H Appel, R Bertoni da Silveira, W Gremski, S S Veiga   +3 more
doaj   +1 more source

Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency [PDF]

Clinical and Vaccine Immunology, 2012
ABSTRACTStaphylococcus aureusalpha toxin (AT) is an important virulence determinant and may be a valid target for immunoprophylaxis against staphylococcal disease. Here we report the identification of potent inhibitory anti-AT monoclonal antibodies (MAbs) derived using B-cell hybridoma technology from VelocImmune mice engineered to produce IgG with a ...
Christine Tkaczyk, L. Hua, Reena Varkey, Yuru Shi, L. Dettinger, Robert M. Woods, Arnita Barnes, Randall S. MacGill, Susan Wilson, Partha S. Chowdhury, C. Kendall Stover, Bret R. Sellman   +11 more
openalex   +3 more sources

Verified envenomations by crevice weaver spiders (genus Kukulcania): Bites are of minor expression but the spiders are commonly misidentified as medically important brown recluses (genus Loxosceles) in North America

Toxicon: X, 2022
From southern North America, five verified bites by crevice weaver spiders, Kukulcania spp. (Filistatidae), are presented here, three of which are pediatric cases. Although the envenomation manifestations were of minimal expression, the salient aspect of
Richard S. Vetter
doaj   +1 more source

Anti-Alpha-Toxin Monoclonal Antibody and Antibiotic Combination Therapy Improves Disease Outcome and Accelerates Healing in a Staphylococcus aureus Dermonecrosis Model [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Alpha-toxin (AT) is a major virulence determinant in Staphylococcus aureus skin and soft tissue infection models. We previously demonstrated that prophylactic administration of 2A3, an AT-neutralizing monoclonal antibody (MAb), prevents S.
Jamese J. Hilliard, Vivekananda Datta, Christine Tkaczyk, Melissa Hamilton, Agnieszka Sadowska, Omari Jones-Nelson, Terrence O’Day, Jason Weiss, Szabolcs Szarka, Vien Nguyen, László Prókai, JoAnn Suzich, C. Kendall Stover, Bret R. Sellman   +13 more
openalex   +4 more sources

Transcriptome and venom proteome of the box jellyfish Chironex fleckeri [PDF]

, 2015
Background: The box jellyfish, Chironex fleckeri, is the largest and most dangerous cubozoan jellyfish to humans. It produces potent and rapid-acting venom and its sting causes severe localized and systemic effects that are potentially life-threatening ...
Brinkman, Diane L., Dash, Debasis, Jia, Xinying, Kumar, Dhirendra, Kvaskoff, David, Mulvenna, Jason, Potriquet, Jeremy   +6 more
core   +1 more source

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease [PDF]

, 2019
Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year.
Bicknell, Andrew, Collins-Hooper, Henry, Layfield, Harry, Matsakas, Antonios, Mellows, Ben, Mitchell, Robert, Patel, Ketan, Salamah, Maryam, Sfyri, Peggy, Vaiyapuri, Raj, Vaiyapuri, Sakthi, Williams, Harry   +11 more
core   +3 more sources

Sphingomyelinase D Activity in Sicarius tropicus Venom : Toxic Potential and Clues to the Evolution of SMases D in the Sicariidae Family [PDF]

, 2021
The spider family Sicariidae includes three genera, Hexophthalma, Sicarius and Loxosceles. The three genera share a common characteristic in their venoms: the presence of Sphingomyelinases D (SMase D).
Bertani, Rogerio, Fukushima, Caroline Sayuri, Lopes, Priscila Hess, Shoji, Rosana, Tambourgi, Denise   +4 more
core   +1 more source

Identification and validation of a linear protective neutralizing epitope in the β-pore domain of alpha toxin. [PDF]

PLoS ONE, 2015
The plethora of virulence factors associated with Staphylococcus aureus make this bacterium an attractive candidate for a molecularly-designed epitope-focused vaccine.
Jon Oscherwitz, Kemp B Cease
doaj   +1 more source

A Polychaete’s Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs [PDF]

, 2014
© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/
Abdel-Rahman, Aird, Alarcon-Chaidez, Altschul, Alves-Silva, Ambrose, Anatriello, Anderluh, Bakrac, Bakrac, Balasubramanian, Barlic, Binford, Binford, Björn M. von Reumont, Bon, Borda, Bradnam, Brinkman, Böggemann, Casewell, Castaneda, Castaneda, Chagas, Chang, Chen, Christoph Bleidorn, Conesa, Conesa, Cuypers, Dan Sykes, Darriba, De Colibus, Earl, Eddy, Fauchald, Favreau, Fernandes-Pedrosa, Francischetti, Fry, Fry, Garb, Garcia, Garcia-Ortega, Ghadessy, Giese, Giray, Grabherr, Hargreaves, He, Honma, Jungo, Jörg Hetmank, Kagan, Katoh, Kawashima, Khalturin, King, King, Kircher, Kiriake, Klawe, Kobayashi, Koua, Krebs, Kristan, Kvist, Lahcen I. Campbell, Lars Hering, Lin, Low, Low, Manaranche, Mancheno, Margres, Martin, Meunier, Meunier, Meyer, Michel, Michel, Min, Morgenstern, Morgenstern, Moses, Nakamura, Olivera, O’Neil, Peng, Pennington, Petersen, Rangaraju, Rigoni, Rokyta, Ronald A. Jenner, Rosenberg, Rouse, Safavi-Hemami, Sandy Richter, Schenning, Shiomi, Shiomi, Smeds, Stamatakis, Sukumwang, Sunagar, Terrat, Ueda, Ungerer, Violette, von Reumont, Vonk, Warren, Watala, Weston, Whittington, Wong, Zdobnov, Zhang, Zimmerberg, Zobel-Thropp   +120 more
core   +1 more source