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Use of des-gamma-carboxyprothrombin in retrospective diagnosis of hidden intoxication of anticoagulants. [PDF]
Journal of Clinical Pathology, 1987 J J Lefrere
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Cancer, 1994
Des-gamma-carboxyprothrombin (DCP) is a useful tumor marker for hepatocellular carcinoma (HCC). The present method for measurement of DCP concentration, however, does not have adequate sensitivity to detect small HCCs.The serum DCP concentration was investigated by the avidin-biotin complex (ABC) method in patients with an HCC smaller than 20 mm in ...
Akihito Tsubota, Isao Koida, I Koida
exaly +3 more sources
Des-gamma-carboxyprothrombin (DCP) is a useful tumor marker for hepatocellular carcinoma (HCC). The present method for measurement of DCP concentration, however, does not have adequate sensitivity to detect small HCCs.The serum DCP concentration was investigated by the avidin-biotin complex (ABC) method in patients with an HCC smaller than 20 mm in ...
Akihito Tsubota, Isao Koida, I Koida
exaly +3 more sources
Journal of Hepatology, 1987
The des-gamma-carboxyprothrombin (DCP) level was found to be increased in the majority of hepatocellular carcinomas (HCC). This increase has to be distinguished from an increased DCP level linked to a vitamin K deficiency. We studied the evolution of increased DCP level in 6 patients with histologically proven HCC and in 10 without HCC after slow ...
Daniel Dhumeaux, M Leclercq, J J Lefrere
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The des-gamma-carboxyprothrombin (DCP) level was found to be increased in the majority of hepatocellular carcinomas (HCC). This increase has to be distinguished from an increased DCP level linked to a vitamin K deficiency. We studied the evolution of increased DCP level in 6 patients with histologically proven HCC and in 10 without HCC after slow ...
Daniel Dhumeaux, M Leclercq, J J Lefrere
exaly +3 more sources
Des-Gamma-Carboxyprothrombin (PIVKA II) and Plasma Vitamin K1 in Newborns and Their Mothers
Thrombosis and Haemostasis, 1992SummaryAssessments of the vitamin K status in newborns and their mothers by means of des-γ-carboxy-prothrombin (PIVKA II) measurement have given equivocal results. Part of the variability could be attributed to differences in sensitivity (i.e. the ability to detect small concentrations) and validity (i.e.
R, von Kries +5 more
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ELECTROPHORESIS, 1991
AbstractIn the absence of vitamin K or in the presence of the vitamin K antagonists, abnormal nonfunctional forms of prothrombin circulate in the blood. A reliable and reproducible technique, derived from traditional crossed affinoimmunoelectrophoresis in presence of calcium lactate, was developed and optimized.
M, Belle +4 more
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AbstractIn the absence of vitamin K or in the presence of the vitamin K antagonists, abnormal nonfunctional forms of prothrombin circulate in the blood. A reliable and reproducible technique, derived from traditional crossed affinoimmunoelectrophoresis in presence of calcium lactate, was developed and optimized.
M, Belle +4 more
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Journal of Immunoassay and Immunochemistry, 1995
In order to explore pathologies possibly associated with vitamin K deficiency, several monoclonal antibodies (mAbs) were produced against human Desgamma-Carboxy-Prothrombin (DCP). One of these mAbs, designated C4B6, detected DCP forms in the presence of Calcium ions, confirmed by comparison with the patterns of two electrophoretic techniques: Affino ...
M Leclercq
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In order to explore pathologies possibly associated with vitamin K deficiency, several monoclonal antibodies (mAbs) were produced against human Desgamma-Carboxy-Prothrombin (DCP). One of these mAbs, designated C4B6, detected DCP forms in the presence of Calcium ions, confirmed by comparison with the patterns of two electrophoretic techniques: Affino ...
M Leclercq
exaly +3 more sources
Journal of Gastroenterology and Hepatology (Australia), 2005
AbstractBackground and Aim: Our aim was to evaluate the heterogeneity of des‐γ‐carboxyprothrombin (DCP) in the plasma of patients with hepatocellular carcinoma (HCC), benign liver diseases, and normal controls and compare the DCP values by enzyme‐linked immunosorbent assay (ELISA) for two types monoclonal antibodies (MU‐3 and 19B7).Methods: We purified
Soichiro, Uehara +4 more
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AbstractBackground and Aim: Our aim was to evaluate the heterogeneity of des‐γ‐carboxyprothrombin (DCP) in the plasma of patients with hepatocellular carcinoma (HCC), benign liver diseases, and normal controls and compare the DCP values by enzyme‐linked immunosorbent assay (ELISA) for two types monoclonal antibodies (MU‐3 and 19B7).Methods: We purified
Soichiro, Uehara +4 more
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The des-gamma-carboxyprothrombin for the diagnosis of hepatocellular carcinoma.
The Italian journal of gastroenterology, 1993Des-gamma-carboxyprothrombin level was measured by enzyme immunoassay in the plasma of 39 patients suffering from hepatocellular carcinoma and 26 controls. Two of these were anticoagulated by warfarin and revealed very high positive values; the remaining 24, 8 healthy subjects and 16 patients with cirrhosis or chronic hepatitis, were negative.
F, Brunello +7 more
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Clinica Chimica Acta, 1999
In the absence of vitamin K (VK) or in the presence of VK antagonists, hepatic VK-dependent carboxylase activity is inhibited and des-gamma-carboxyprothrombin (DCP) is released into the blood. We analyzed the number of glutamic acid (Glu) residues and their positions in the Gla domain (GD) of DCP to investigate the gamma-carboxylation mechanism of VK ...
Akio Hirayama, Soichiro Uehara
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In the absence of vitamin K (VK) or in the presence of VK antagonists, hepatic VK-dependent carboxylase activity is inhibited and des-gamma-carboxyprothrombin (DCP) is released into the blood. We analyzed the number of glutamic acid (Glu) residues and their positions in the Gla domain (GD) of DCP to investigate the gamma-carboxylation mechanism of VK ...
Akio Hirayama, Soichiro Uehara
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The role of des-gamma-carboxyprothrombin expression in hepatocellular carcinoma.
Hepato-gastroenterology, 2009Des-gamma-carboxyprothrombin (DCP), is a well-known tumor marker of hepatocellular carcinoma (HCC). On the other hand, some reports suggest that tissue expression of DCP is more useful as a prognostic factor than the serum DCP value. The aim of this study is to clarify the clinicopathological role of expression of DCP on HCC, especially when there is a
Yukari, Harino +6 more
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