Results 61 to 70 of about 12,988 (223)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Controllable self‐transport of bouncing droplets on ultraslippery surfaces with wedge‐shaped grooves
DropletPreventing the accretion of droplets on surfaces is vital and slippery liquid‐infused porous surfaces (SLIPS) have promising application prospects, such as surface self‐cleaning and droplet transportation.
Chuchen Yue +5 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Extraordinary stability of surfactant‐free bubbles suspended in ultrasound
DropletGravity‐induced drainage is one of the main destabilizing mechanisms for soap bubbles and foams. Here we show that solely through acoustic levitation without introducing any chemical stabilizers, liquid drainage in the bubble film can be completely ...
Xiaoliang Ji +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
DropletEngineered topologies on superwetting with special wettability provide tailored functionalities and precise control over wetting and droplet behaviors, setting them apart from randomly structured surfaces.
Sin‐Yung Siu +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Large contact angle hysteresis enhances post‐impact droplet oscillations
DropletDroplet impact on solid surfaces plays a critical role in a wide range of applications, including inkjet printing, spray cooling, surface coatings, and microdroplet chemistry.
Pengfei Zhao +7 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source