Results 71 to 80 of about 5,615 (204)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamics of cavitation bubbles in a liquid layer

Droplet
Cavitation phenomena are widespread in nature and industrial applications. Researchers have conducted in‐depth studies on the interaction of cavitation bubbles with a single boundary. However, when cavitation bubbles interact simultaneously with multiple
Jinzhao Liu, Tianyou Wang, Zhizhao Che
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Goose‐bumpy materials

Droplet, 2022
David Quéré
doaj   +1 more source

Dynamic manipulation of multiphase fluid in microgravity using photoresponsive surfactant

Droplet
Control of bubble motion is essential for improving efficiency and creating new functionalities in electrochemistry, heat transfer, and biomedical systems.
Xichen Liang, Kseniia M. Karnaukh, Qixuan Cao, Marielle Cooper, Hao Xu, Ian Maskiewicz, Olivia Wander, Javier Read de Alaniz, Yangying Zhu, Paolo Luzzatto‐Fegiz   +9 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Making use of water droplets as a sustainable green energy source

Droplet, 2022
Yanqin Yang, Chengkuo Lee
doaj   +1 more source

Manipulating drying‐induced carbon nanotube assemblies through substrate surface engineering

Droplet
The unique one‐dimensional structure and outstanding optoelectronic properties of carbon nanotubes (CNTs) have motivated extensive research into their directed assembly.
Ke Shui, Deng Pan, Tongtong Qin, Wenxin Xiao, Xin Li, Hao Yang, Jian Lin, Qingguang Xie, Jens Harting, Song Qiu, Chang‐Qi Ma   +10 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Enhancing hydrogen evolution reaction by harnessing bubble dynamics regulation: Principles, methods, and outlook

Droplet
Electrocatalytic hydrogen evolution reaction (HER) is crucial for green hydrogen production and the transition toward low‐carbon energy systems. However, the issues related to electrochemical gas bubbles, particularly at high current densities, have ...
Ziwei Guo, Chunhui Zhang, Yunxun Liu, Yi Han, Jinghang Pan, Lingyao Zhang, Chuanqi Nie, Yuejing Zhao, Kesong Liu, Cunming Yu, Lei Jiang   +10 more
doaj   +1 more source