Results 71 to 80 of about 14,044 (255)
High‐throughput generation of aqueous two‐phase microcapsules using microfluidic bubble triggering
DropletHydrogel microcapsules are powerful microreactor vessels that have attracted widespread attention and research. Among the various methods for their generation, the aqueous two‐phase system (ATPS) is by far the most straightforward approach.
Sixiang Rao +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Repair Connection with Wooden Wedged Dowels: Preliminary Experimental Laboratory Tests and FEM Model for the Description of the Mechanical Behavior [PDF]
12th International Conference on Structural Analysis of Historical Constructions, 2021 E. Perria, S. Siegert, X. Li, M. Sieder
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DropletWhen microdroplets with quasi‐spherical contact angles coalesce together on a low‐adhesion substrate, the capillary‐inertial expansion of the liquid bridge induces a dramatic out‐of‐plane jumping event due to symmetry breaking. From the onset of merging,
Jonathan B. Boreyko
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Droplet collision of hypergolic propellants
DropletIn the present mini‐review, droplet impacting on a liquid pool, jet impingement, and binary droplet collision of nonreacting liquids are first summarized in terms of basic phenomena and the corresponding nondimensional parameters.
Chengming He, ZhiXia He, Peng Zhang
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Making use of water droplets as a sustainable green energy source
Droplet, 2022 Yanqin Yang, Chengkuo Lee
doaj +1 more source