Results 61 to 70 of about 5,615 (204)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Evolution of the water cluster in pore condensation
DropletPore condensation enables vapor‐liquid transitions below saturation humidity, yet the microscopic dynamics of the embryo formation and cluster growth within the pore remain unresolved.
Boxuan Cui +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DropletMiniaturized functional fluidic pumps have found broad applications across various fields; however, the fabrication and dimensional limitations of their electrodes remain a significant challenge.
Zebing Mao +9 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Energy harvesting meets superhydrophobic surfaces: Recent advances
DropletAmbient energy harvesting from various renewable sources, including solar, thermal, wave, droplet, wind, and biomechanical energy, presents a promising solution for sustainable power generation and battery‐free Internet of Things networks. However, these
Leiyang Wang +4 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
High‐throughput generation of aqueous two‐phase microcapsules using microfluidic bubble triggering
DropletHydrogel microcapsules are powerful microreactor vessels that have attracted widespread attention and research. Among the various methods for their generation, the aqueous two‐phase system (ATPS) is by far the most straightforward approach.
Sixiang Rao +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Beyond goniometry: 3D digital twinning of droplets from a single image
DropletWettability characterizations are crucial to many disciplines, including dropwise condensation heat transfer, microfluidics, and self‐cleaning materials.
Isaac Berk, Emilie Luong, H. Jeremy Cho
doaj +1 more source