Results 71 to 80 of about 12,988 (223)

Dielectrowetting of sessile droplets of smectic liquid crystals

Droplet
We report on the dielectrowetting of sessile droplets of two common liquid crystals, 4‐cyano‐4′‐pentylbiphenyl (5CB) and 4‐cyano‐4′‐n‐octylbiphenyl (8CB), deposited on interdigitated electrodes that were treated to induce homeotropic anchoring.
Filippo Marinello, Giovanni Bexon, Davide Ferraro, Matteo Pierno, Bruno Zappone, Giampaolo Mistura   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Biomimetic chloroplasts: Two‐phase microfluidic platforms with selective permeability for artificial photosynthesis

Droplet
The development of biomimetic chloroplasts offers significant potential in addressing global energy and environmental challenges. Traditional droplet‐based models are limited by transmembrane transport inefficiencies, leading to the accumulation of ...
Guanxiong Wang, Meiying Hong, Chonghui Yang, Menghan Yang, Gaozhen Zhao, Haixia Liu, Rui Shen, Siping Wang, Xuming Zhang, Xiaowen Huang, Yaolei Wang   +10 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rapid detection and quantification of ultralow‐concentration nanoparticles based on nanopore array blockage

Droplet
Rapid and accurate detection of ultralow‐concentration nanoparticles is crucial for applications ranging from medical diagnosis to water quality monitoring, yet remains challenging for current laser‐based and light‐scattering methods.
Rami Yazbeck, Jiayi Xu, Yiding Zhong, Yixin Xu, Liangwei Zheng, Bernie Xu, Chuanhua Duan   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Solidification characteristics of two‐dimensional water droplets

Droplet
Frost and ice are ubiquitous in nature and industry, and sometimes cause problems. The solidification of water droplets is in the early stage of frosting and icing and has attracted extensive research interest.
Mengjie Song, Runmiao Gao, Chaobin Dang, Keke Shao, Long Zhang   +4 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Ethanol evaporation drives ester assembly and particle deposition in droplets of Chinese distilled liquors

Droplet
Chinese distilled liquor, known as Baijiu, typically has a relatively high ethanol content (52 or 53% alcohol by volume, ABV) and is characterized by a powerful, heady scent.
Zhi Zhang, Haoran Fu, Yang Zhong, Lu Cai, Keyi Zuo, Shiyuan Deng, Tieyuan Cheng, Bo Gao, Ning Wang, Jun Liu, Zaixin Li, Huibo Luo, Siqi Yuan, Duyang Zang, Yongming Liu   +14 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source