Results 171 to 180 of about 131,957 (312)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Physicochemical, Predicted ADME, and Structural Positioning of Azelaic Acid Within an Endocrine Oncology Reference Framework. [PDF]

Pharmaceuticals (Basel)
Jurj ED, Voicu A, Colibășanu D, Voicu M, Nicolov M, Udrescu L.   +5 more
europepmc   +1 more source

A data-driven methodology for solving the control strategy of descriptor systems

, 2013
This paper is concerned with the reinforcement learning methods for the discrete time descriptor systems. An algorithm, as well as its theoretical basis, is presented.
Li JN(李金娜), Li, Mengmeng, Zhang DQ(张大庆)   +2 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Stability and Test-Retest Reliability of the Individual Acoustic Reference for Within-Subject Analysis of Hearing Device-Processed Speech: The SpettroREM Method. [PDF]

Audiol Res
Burdo S, Carini E, Impalà G, Brotto D.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

RACE: A Modular and Interpretable Radial-Angular Correlation Descriptor for Atomistic Machine Learning. [PDF]

J Chem Theory Comput
Tromer RM, de Lima J, Woellner CF, Barbosa PF, Santos RV, Ribeiro Junior LA.   +5 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

AI-Driven Nano-QSAR Framework for Predicting Carbon Nanotube Cytotoxicity: Overcoming High Dimensionality and Data Imbalance. [PDF]

Int J Nanomedicine
Song Z, Zhang F, Zhou Y, Shao L, Liu J, Lai P, Huang X.   +6 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source