Results 161 to 170 of about 53,511 (260)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Descriptor-driven design of carbon nitride for visible light photocatalysis
Photocatalysis utilizing carbon nitride (CN) based photocatalysts presents an eco-friendly solution to energy challenges. Despite progress in enhancing CN performance, targeted design for specific applications remains challenging due to the complex ...
Haoxin Mai (18032953) +12 more
core
Statistical layout of improved image descriptor for pedestrian detection
, 2010 An automatic and robust approach for pedestrian detection is proposed in natural scene images, even in the presence of clutter and occlusion. An improved statistical descriptor is designed to encode more support vectors, and the dimensionality reduction ...
Zhuang Y(庄严) +2 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A data-driven methodology for solving the control strategy of descriptor systems
, 2013 This paper is concerned with the reinforcement learning methods for the discrete time descriptor systems. An algorithm, as well as its theoretical basis, is presented.
Li JN(李金娜) +2 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Integrating kAS and SIFT-like descriptor for image description
, 2011 Shape-descriptor (e.g. Adjacent Contour Segments, i.e. kAS) and keypoint-descriptor (e.g. Scale Invariant Feature Transform, i.e. SIFT) are widely used for computer vision. However, few works principally integrate shape-descriptor and keypoint-descriptor
PangYanwei +3 more
core