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Desensitization: Overcoming the Immunologic Barriers to Transplantation [PDF]

Journal of Immunology Research, 2017
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after ...
Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan   +5 more
doaj   +5 more sources

Excellent outcome after desensitization in high immunologic risk kidney transplantation.

PLoS ONE, 2019
INTRODUCTION:HLA-incompatible (HLAi) and ABO-incompatible (ABOi) kidney transplantation (KT) has been on the increase over the last decade. However, there are wide variations in outcomes from these procedures.
Jeong-Hoon Lim, Jang-Hee Cho, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Dong-Il Won, Chan-Duck Kim   +10 more
doaj   +5 more sources

Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. [PDF]

Journal of Allergy and Clinical Immunology, 2011
There are no treatments currently available for peanut allergy. Sublingual immunotherapy (SLIT) is a novel approach to the treatment of peanut allergy.We sought to investigate the safety, clinical effectiveness, and immunologic changes with SLIT in children with peanut allergy.In this double-blind, placebo-controlled study subjects underwent 6 months ...
Edwin H. Kim, J. Bird, M. Kulis, S. Laubach, L. Pons, W. Shreffler, Pamela H. Steele, J. Kamilaris, B. Vickery, A. Burks   +9 more
semanticscholar   +3 more sources

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
doaj   +2 more sources

Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization. [PDF]

Journal of Allergy and Clinical Immunology, 2019
Peanut sublingual immunotherapy (SLIT) for 1 year has been shown to induce modest clinical desensitization in allergic children. Studies of oral immunotherapy, epicutaneous immunotherapy, and SLIT have suggested additional benefit with extended treatment.We sought to investigate the safety, clinical effectiveness, and immunologic changes with long-term
Edwin H. Kim, Luanna Yang, Ping Ye, R. Guo, Quefeng Li, M. Kulis, A. Burks   +6 more
semanticscholar   +3 more sources

Novel pretransplant desensitization strategies in heart transplantation [PDF]

JHLT Open
Allosensitization remains a major barrier in thoracic organ transplantation, limiting access to transplantation and increasing waitlist mortality and post-transplant morbidity.
Guillaume Coutance, MD, PhD, Anita S. Chong, PhD, Marlena V. Habal, MD   +2 more
doaj   +2 more sources

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons [PDF]

Frontiers in Immunology
With the recent FDA approval of the anti-IgE biologic, omalizumab, in 2024 for the treatment of food allergy, it is critical to consider the advantages and disadvantages of anti-IgE and allergen-specific immunotherapies (AITs) to help determine optimal ...
Michael D. Kulis, Jessica R. Humphrey, James W. Krempski, Edwin H. Kim, Johanna M. Smeekens, Johanna M. Smeekens   +5 more
doaj   +2 more sources

Immunologic observations during desensitization and maintenance of clinical tolerance to penicillin.

Journal of Allergy and Clinical Immunology, 1983
A nurse anesthetist who had experienced four systemic allergic reactions attributed to penicillin exposure was safely and successfully desensitized to penicillin despite predominantly minor determinant allergy (benzyl penicilloate skin test was positive at 1:100,000 dilution of standard 10 mM solution).
R. Naclerio, Edward A. Mizrahi, N. Adkinson   +2 more
semanticscholar   +3 more sources

Egg desensitization is achieved effectively and safely through a low maintenance dose protocol [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure.
Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD   +9 more
doaj   +2 more sources

Considerations for biologics as front-line treatment in allergic diseases [PDF]

Frontiers in Immunology
The therapeutic landscape of allergic diseases has been transformed by the advent of biologics targeting key immunologic pathways. These therapies offer disease-modifying potential across a spectrum of conditions including asthma, atopic dermatitis ...
Akash Kothari, Lisa Hung, Julia E. M. Upton, Julia E. M. Upton   +3 more
doaj   +2 more sources