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Desensitization: Overcoming the Immunologic Barriers to Transplantation [PDF]

Journal of Immunology Research, 2017
HLA (Human Leucocyte Antigen) sensitization is a significant barrier to successful kidney transplantation. It often translates into difficult crossmatch before transplant and increased risk of acute and chronic antibody mediated rejection after ...
Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan   +5 more
doaj   +5 more sources

Excellent outcome after desensitization in high immunologic risk kidney transplantation.

PLoS ONE, 2019
INTRODUCTION:HLA-incompatible (HLAi) and ABO-incompatible (ABOi) kidney transplantation (KT) has been on the increase over the last decade. However, there are wide variations in outcomes from these procedures.
Jeong-Hoon Lim, Jang-Hee Cho, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Yong-Lim Kim, Hyung-Kee Kim, Seung Huh, Eun Sang Yoo, Dong-Il Won, Chan-Duck Kim   +10 more
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Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Blood Advances, 2017
: The detrimental effects of donor-directed antibodies in sensitized transplant patients remain a difficult immunologic barrier to successful organ transplantation. Antibody removal is often followed by rebound.
Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S. Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B. Farris, Allan D. Kirk, Stuart J. Knechtle   +12 more
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Novel pretransplant desensitization strategies in heart transplantation [PDF]

JHLT Open
Allosensitization remains a major barrier in thoracic organ transplantation, limiting access to transplantation and increasing waitlist mortality and post-transplant morbidity.
Guillaume Coutance, MD, PhD, Anita S. Chong, PhD, Marlena V. Habal, MD   +2 more
doaj   +2 more sources

Anti-IgE therapy versus allergen-specific immunotherapy for food allergy: weighing the pros and cons [PDF]

Frontiers in Immunology
With the recent FDA approval of the anti-IgE biologic, omalizumab, in 2024 for the treatment of food allergy, it is critical to consider the advantages and disadvantages of anti-IgE and allergen-specific immunotherapies (AITs) to help determine optimal ...
Michael D. Kulis, Jessica R. Humphrey, James W. Krempski, Edwin H. Kim, Johanna M. Smeekens, Johanna M. Smeekens   +5 more
doaj   +2 more sources

Egg desensitization is achieved effectively and safely through a low maintenance dose protocol [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure.
Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD   +9 more
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Considerations for biologics as front-line treatment in allergic diseases [PDF]

Frontiers in Immunology
The therapeutic landscape of allergic diseases has been transformed by the advent of biologics targeting key immunologic pathways. These therapies offer disease-modifying potential across a spectrum of conditions including asthma, atopic dermatitis ...
Akash Kothari, Lisa Hung, Julia E. M. Upton, Julia E. M. Upton   +3 more
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Biologics in IgE-mediated food allergy: A systematic review and meta-analysis of interventional studies [PDF]

World Allergy Organization Journal
Background and aims: IgE-mediated food allergy (FA) is a major healthcare problem, affecting millions of children and adults worldwide. FA management usually involves elimination diets; however, there is increasing interest in alternative strategies that
Ulugbek B. Nurmatov, MSc, MPH, MD, PhD, Lucia Lo Scalzo, MD, Francesca Galletta, MD, Marianna Krasnenkova, MD, PhD, Stefania Arasi, MSc, MD, PhD, Ignacio J. Ansotegui, MD, PhD, Nara Tagiyeva-Milne, MD, MPH, PhD, Alessandro Fiocchi, MD   +7 more
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Desensitization for the prevention of drug hypersensitivity reactions [PDF]

The Korean Journal of Internal Medicine, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Sung-Yoon Kang, Jeongmin Seo, Hye-Ryun Kang   +2 more
doaj   +1 more source

Prophylactic vaccinations management in patients undergoing allergen immunotherapy – a review

Family Medicine & Primary Care Review, 2022
Allergen immunotherapy (AIT) is the only casual method of allergy treatment. It is based on regular administration of a gradually increasing dose of an allergen to induce immunological tolerance to a particular sensitising factor. Due to proven efficacy,
Ewa Czerwińska, Marita Nittner-Marszalska, Agnieszka Mastalerz-Migas, Leszek Szenborn   +3 more
doaj   +1 more source