Results 91 to 100 of about 7,110 (229)

Modelling Immunological Memory [PDF]

In Silico Immunology, 83-108, 2006, 2010
Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of ...
arxiv  

Immunological recognition by artificial neural networks [PDF]

, 2018
The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on the integrated binding affinity between TCRs and antigenic peptides. To address this problem, we examine whether the
arxiv   +1 more source

Assessment of Spinster homologue 2 (Spns2)‐dependent transport of sphingosine‐1‐phosphate as a therapeutic target

British Journal of Pharmacology, Volume 182, Issue 9, Page 2014-2030, May 2025.
Abstract Background and Purpose Sphingosine‐1‐phosphate (S1P) receptor modulator (SRM) drugs suppress immune system function by disrupting lymphocyte trafficking, but SRMs are broadly immunosuppressive with on‐target liabilities. Another strategy to modulate the immune system is to block S1P transport.
Yugesh Kharel, Tao Huang, Kyle Dunnavant, Daniel Foster, George M. P. R. Souza, Katherine E. Nimchuk, Andrea R. Merchak, Caitlin M. Pavelec, Zuzanna J. Juskiewicz, Simon S. Alexander, Alban Gaultier, Stephen B. G. Abbott, Jung‐Bum Shin, Brant E. Isakson, Wehao Xu, Norbert Leitinger, Webster L. Santos, Kevin R. Lynch   +17 more
wiley   +1 more source

Fatal outcome of anaphylaxis – triggers, cofactors, management, prevention and forensic aspects

Annales Academiae Medicae Silesiensis
Anaphylaxis is a life-threatening condition characterized by a rapid onset, requiring immediate intervention. It occurs through immunologic or non-immunologic mechanisms and can be triggered by various factors such as foods, medications or insect venoms.
Maciej Kycler, Szymon Rzepczyk, Paweł Świderski   +2 more
doaj   +1 more source

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report [PDF]

, 2018
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144684/1/ajt14752_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144684/2/ajt14752 ...
Askar, Medhat, Campbell, Patricia, Chandraker, Anil, Chang, Patricia P., Claas, Frans H., Colvin, Monica, Demetris, Anthony‐jake, Diamond, Joshua M., Dipchand, Anne I., Fairchild, Robert L., Feng, Sandy, Ford, Mandy L., Friedewald, John, Gebel, Howard M., Gill, Ronald G., Glotz, Denis, Goldberg, Hilary, Hachem, Ramsey, Jackson, Annette M., Knechtle, Stuart, Kobashigawa, Jon, Levine, Deborah J., Levitsky, Joshua, Mannon, Roslyn B., Mengel, Michael, Milford, Edgar, Newell, Kenneth A., Nickerson, Peter, O’leary, Jacqueline G., Palmer, Scott, Randhawa, Parmjeet, Reed, Elaine F., Smith, John, Snyder, Laurie, Starling, Randall C., Sweet, Stuart, Tambur, Anat R., Taner, Timucin, Taylor, Craig J., Tinckam, Kathryn, Woodle, Steve, Zeevi, Adriana   +41 more
core   +1 more source

An algorithm for the diagnosis and treatment of nonsteroidal antiinflammatory drugs hypersensitivity, 2024 update

Allergy, Volume 80, Issue 4, Page 1183-1186, April 2025.
Inmaculada Doña, Rocío Sáenz de Santa María, Esther María Moreno, Joan Bartra, María José Torres   +4 more
wiley   +1 more source

STAT3 Inhibition Prevents Adaptive Resistance and Augments NK Cell Cytotoxicity to KRASG12C Inhibitors in Nonsmall Cell Lung Cancer

Cancer Science, Volume 116, Issue 5, Page 1375-1391, May 2025.
Napabucasin, combined with sotorasib, not only exerted tumor growth suppression via interruption of both KRAS and STAT3 pathways but also augmented the infiltration and activation of NK cells through down‐regulating inhibitory ligand HLA‐B transcription.
Zehao Pan, Yuxian Qian, Yajing Wang, Te Zhang, Xuming Song, Hanling Ding, Rutao Li, Yijian Zhang, Zi Wang, Hui Wang, Wenjie Xia, Lei Wei, Lin Xu, Gaochao Dong, Feng Jiang   +14 more
wiley   +1 more source

Food allergy: recent advances in pathophysiology and treatment [PDF]

, 2009
Food allergies are adverse immune reactions to food proteins that affect up to 6% of children and 3-4% of adults. A wide range of symptoms can occur depending on whether IgE or non-IgE mediated mechanism are involved.
Akdis, Alonso, Bannon, Bashir, Beyer, Bissonnette, Bock, Bock, Bohle, Boyano Martinez, Bryan, Casale, Cerecedo, Chase, Chehade, Chu, Cohen, Cortes-Perez, Czarnecka-Operacz, Du Toit, Enrique, Enrique, Fernandez-Rivas, Fleischer, Flinterman, Garcia-Ara, Grundy, Hill, Hill, Hong, Horner, Hugh A Sampson, Jarvinen, Jarvinen, Joint Task Force on Practice Parameters, Jones, Julie Wang, Karlsson, Khodoun, Kinaciyan, King, Ko, Lack, Lake, Leung, Li, Li, Li, Liacouras, Longo, Ma, Milgrom, Miller, Mishra, Morafo, Nelson, Niederberger, Noel, Nowak-Wegrzyn, Oppenheimer, Perry, Pierkes, Pumphrey, Rona, Roy, Saltoun, Sampson, Sampson, Sampson, Savage, Shek, Shreffler, Shreffler, Sicherer, Sicherer, Skolnick, Skripak, Skripak, Spergel, Spergel, Srivastava, Srivastava, Srivastava, Srivastava, Staden, Stein, Straumann, Strid, Strobel, Sudo, Swoboda, Takagi, Tighe, Torgerson, Untersmayr, Untersmayr, Vadas, Wang, Wang, Yu, Zhang, Zhu, Zhu   +102 more
core   +2 more sources

Desensitized Kalman Filtering with Analytical Gain [PDF]

arXiv, 2015
The possible methodologies to handle the uncertain parameter are reviewed. The core idea of the desensitized Kalman filter is introduced. A new cost function consisting of a posterior covariance trace and trace of a weighted norm of the state error sensitivities matrix is minimizing to obtain a well-known analytical gain matrix, which is different from
arxiv  

Pea proteins immunotherapy in peanut allergic mice model [PDF]

, 2014
Mice (Balb/c), with peanut allergy induced, were subjected to desensitization therapy with the use of pea protein extract (PE) or isolated globulin fractions: legumin (PL) and vicilin (PV).
Chudzik-Kozłowska, J., Szymkiewicz, A.
core   +1 more source