Results 101 to 110 of about 412,458 (245)

Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome

Sexual Medicine, 2018
Post-orgasmic illness syndrome (POIS) is a very rare disease characterized by local allergic symptoms and transient flu-like illness that nearly always occur after masturbation, coitus, or spontaneous ejaculation and last for 2 to 7 days.
Tae Beom Kim, MD, PhD, Young Sup Shim, MD, PhD, Sang Min Lee, MD, PhD, Eun Suk Son, PhD, Jung Woo Shim, MD, Sang Pyo Lee, MD, PhD   +5 more
doaj   +1 more source

Pilot Study: Program Evaluation of Peanut Oral Immunotherapy in a Private Clinic [PDF]

, 2019
The privilege of providing a therapy perceived by patients and families as “life changing” has seasoned physicians describing food oral immunotherapy (OIT) as one of “the most impactful and rewarding thing that they have done in medicine” (Wasserman ...
Olson, Kinga
core   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Alergia e intolerancia a antiinflamatorios no esteroides: desensibilización exitosa en tres casos y revisión de la literatura

Biomédica: revista del Instituto Nacional de Salud, 2009
Los antiinflamatorios no esteroides son la segunda causa de reacciones a medicamentos después de los beta-lactámicos. La prevalencia de las reacciones a antiinflamatorios no esteroideos en la población general es de 0,1% a 0,3% y la prevalencia de ...
Ricardo Cardona, Ruth Helena Ramírez, Zulma Reina, Mauricio Fernando Escobar, Edison Morales   +4 more
doaj   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Fatal outcome of anaphylaxis – triggers, cofactors, management, prevention and forensic aspects

Annales Academiae Medicae Silesiensis
Anaphylaxis is a life-threatening condition characterized by a rapid onset, requiring immediate intervention. It occurs through immunologic or non-immunologic mechanisms and can be triggered by various factors such as foods, medications or insect venoms.
Maciej Kycler, Szymon Rzepczyk, Paweł Świderski   +2 more
doaj   +1 more source

ABO-incompatible Organs a Viable and Necessary Source for Transplants [PDF]

, 2014
Despite the astounding technological advancements of modern society, failure to receive a timely organ transplant accounts for the death of approximately 18 U.S. citizens each day.
Macpherson, Rachel J
core  

Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis [PDF]

, 2013
The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe consumption of foods containing these aller- gens in patients with food allergies.
Deveraux, Graham, Healy, Laura, Nurmatov, Ulugbek, Sheikh, Aziz, Worth, Alison   +4 more
core   +3 more sources

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source