Results 121 to 130 of about 7,110 (229)

Akt Activation With IPL344 Treatment for Amyotrophic Lateral Sclerosis: First in Human, Open‐Label Study

Muscle &Nerve, Volume 71, Issue 6, Page 1032-1042, June 2025.
ABSTRACT Introduction/Aims Akt intracellular signal transduction pathway dysfunction has been reported in people with amyotrophic lateral sclerosis (ALS) providing a novel target for intervention in this devastating progressive disease. This first‐in‐human study evaluated the safety, tolerability, and preliminary efficacy of the Akt pathway activator ...
Marc Gotkine, David A. Schoenfeld, Ilana Cohen, Jeremy M. Shefner, Yossef Lerner, Irun R. Cohen, Colin Klein, Eran Ovadia, Merit E. Cudkowicz, the Pooled Resource Open‐Access ALS Clinical Trials Consortium   +9 more
wiley   +1 more source

One Year of Oral Immunotherapy Impacts the Gut Microbiota and Plasma Metabolome of Peanut‐Allergic Young Children

Clinical &Experimental Allergy, Volume 55, Issue 4, Page 340-343, April 2025.
Isabella Badolati, Ymke de Jong, Carina Uhl, Josefin Ullberg, Marleen Joustra, Ulrika Lorentzon Fagerberg, Caroline Nilsson, Anna Asarnoj, Eva Sverremark‐Ekström   +8 more
wiley   +1 more source

Histologic and molecular features shared between antibody‐mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis

The Journal of Pathology, Volume 266, Issue 2, Page 177-191, June 2025.
Abstract Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a ‘maternal‐foetal rejection’ mechanism, because at least some CHI cases fulfil the criteria for antibody‐mediated ...
Léonie Albersammer, Juliette Leon, Jelena Martinovic, Jessy Dagobert, Emilie Lebraud, Bettina Bessières, Laurence Loeuillet, Maëva Eloudzeri, Alexandre J. Vivanti, Grégoire Dumery, Valérie Marchaudon, Cristina Antal, Anne‐Sophie Korganow, Thibaud Quibel, Nathalie Costedoat‐Chalumeau, Vassilis Tsatsaris, Alexandra Benachi, Julien Zuber, Marion Rabant   +18 more
wiley   +1 more source

Desensitized Optimal Guidance Using Adaptive Radau Collocation [PDF]

arXiv
An optimal guidance method is developed that reduces sensitivity to parameters in the dynamic model. The method combines a previously developed method for guidance and control using adaptive Legendre-Gauss-Radau (LGR) collocation and a previously developed approach for desensitized optimal control.
arxiv  

A Beginners Guide to Systems Simulation in Immunology [PDF]

arXiv, 2013
Some common systems modelling and simulation approaches for immune problems are Monte Carlo simulations, system dynamics, discrete-event simulation and agent-based simulation. These methods, however, are still not widely adopted in immunology research.
arxiv  

New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient [PDF]

, 2020
Allergic diseases are the most prevalent immunopathologies worldwide. Nowadays, allergen avoidance is the unique effective treatment for allergic patients.
Docena, Guillermo Horacio, Smaldini, Paola Lorena   +1 more
core  

DePrompt: Desensitization and Evaluation of Personal Identifiable Information in Large Language Model Prompts [PDF]

arXiv
Prompt serves as a crucial link in interacting with large language models (LLMs), widely impacting the accuracy and interpretability of model outputs. However, acquiring accurate and high-quality responses necessitates precise prompts, which inevitably pose significant risks of personal identifiable information (PII) leakage.
arxiv  

Anti-adversarial Learning: Desensitizing Prompts for Large Language Models [PDF]

arXiv
With the widespread use of LLMs, preserving privacy in user prompts has become crucial, as prompts risk exposing privacy and sensitive data to the cloud LLMs. Traditional techniques like homomorphic encryption, secure multi-party computation, and federated learning face challenges due to heavy computational costs and user participation requirements ...
arxiv  

Intralymphatic Immunotherapy With Autologous Semen in a Korean Man With Post-Orgasmic Illness Syndrome

Sexual Medicine, 2018
Post-orgasmic illness syndrome (POIS) is a very rare disease characterized by local allergic symptoms and transient flu-like illness that nearly always occur after masturbation, coitus, or spontaneous ejaculation and last for 2 to 7 days.
Tae Beom Kim, MD, PhD, Young Sup Shim, MD, PhD, Sang Min Lee, MD, PhD, Eun Suk Son, PhD, Jung Woo Shim, MD, Sang Pyo Lee, MD, PhD   +5 more
doaj  

Impact of Hymenoptera venom allergy and the effects of specific venom immunotherapy on mast cell metabolites in sensitized children

Annals of Agricultural and Environmental Medicine, 2014
introduction and objective. Mast cells (MC) are effector cells during severe systemic reactions (SR) to Hymenoptera stings. Venom specific immunotherapy (VIT) is the treatment of choice for prevention of SR to stings. Tryptase and prostaglandin D[sub]2[
Ewa Cichocka-Jarosz, Marek Sanak, Andrzej Szczeklik , Piotr Brzyski, Jacek J. Pietrzyk   +4 more
doaj