Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology
Angewandte Chemie, EarlyView.Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker +3 more
wiley +2 more sources
A practical view of immunotherapy for food allergy [PDF]
Korean Journal of Pediatrics, 2016 Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy.
Tae Won Song
doaj +1 more source
Transplant outcomes in positive complement-dependent cytotoxicity- versus flow cytometry-crossmatch kidney transplant recipients after successful desensitization: a retrospective study [PDF]
, 2019 BACKGROUND: Despite the obvious survival benefit compared to that among waitlist patients, outcomes of positive crossmatch kidney transplantation (KT) are generally inferior to those of human leukocyte antigen (HLA)-compatible KT.
김덕기 +8 more
core +1 more source
Basic and clinical immunology – 3016. Successful desensitization to oxaliplatin for metastic colorectal carcinoma [PDF]
World Allergy Organization Journal, 2013 Method In this case a premedication protocol of dexamethasone 10 mg + diphenhydramine 50 mg + famotidine 20 mg by mouth were administered 13 hours, 6 hours and 1 hour respectively prior to the infusion of 40 mg of oxaliplatin in 1:10000, 1:1000, 1:100, 1:10 graded dilutions. Each dilution was infused over 1 hour under close telemetry monitoring.
Malik Baz, Praveen Buddiga
openaire +2 more sources
Immunological barriers in ABO-incompatible kidney transplantation: How to overcome
Indian Journal of Transplantation, 2019 Background: Various desensitization strategies are used to overcome immunologic barriers such as anti-human leukocyte antigen-donor-specific antibody (HLA-DSA) and anti-ABO blood group incompatibility.
Sonia Mehrotra, Raj Kumar Sharma
doaj +1 more source
B-cell Complement Dependent Cytotoxic Crossmatch Positivity is an Independent Risk Factor for Long-term Renal Allograft Survival [PDF]
, 2011 The clinical significance of positive B-cell complement-dependent cytotoxicity crossmatching (B-CDC) in renal transplant recipients remains unclear. We reviewed 20 recipients with isolated B-CDC positivity at the time of transplantation.
Ahern +31 more
core +2 more sources
Annals of Agricultural and Environmental Medicine, 2015 SLIT ( sublingual immunotherapy ) induces allergen-specific immune tolerance by sublingual administration of a gradually increasing dose of an allergen.
Marek Jutel +10 more
doaj +1 more source
The future outlook on allergen immunotherapy in children: 2018 and beyond. [PDF]
, 2018 Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases.
Arasi S, Corsello G, Pajno GB, Villani A
core +2 more sources
ADD: An Automatic Desensitization Fisheye Dataset for Autonomous Driving [PDF]
Engineering Applications of Artificial Intelligence 2023, 2023 Autonomous driving systems require many images for analyzing the surrounding environment. However, there is fewer data protection for private information among these captured images, such as pedestrian faces or vehicle license plates, which has become a significant issue. In this paper, in response to the call for data security laws and regulations and
arxiv
Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization [PDF]
Journal of Allergy and Clinical Immunology, 2019 Peanut sublingual immunotherapy (SLIT) for 1 year has been shown to induce modest clinical desensitization in allergic children. Studies of oral immunotherapy, epicutaneous immunotherapy, and SLIT have suggested additional benefit with extended treatment.We sought to investigate the safety, clinical effectiveness, and immunologic changes with long-term
Edwin H. Kim +6 more
openaire +3 more sources