Results 41 to 50 of about 91,740 (302)

Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]

, 2007
Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core   +1 more source

Intrauterine desensitization enables long term survival of human oligodendrocyte progenitor cells without immunosuppression

iScience, 2023
Summary: Immune rejection can be reduced using immunosuppressants which are not viable for premature infants. However, desensitization can induce immune tolerance for premature infants because of underdeveloped immune system.
Dou Ye, Suqing Qu, Yinxiang Yang, Zhaoyan Wang, Qian Wang, Weipeng Liu, Fan Zhang, Qian Guan, Xiaohua Wang, Jing Zang, Xin Li, Hengtao Liu, Ruiqin Yao, Zhichun Feng, Zuo Luan   +14 more
doaj   +1 more source

Desensitization to drugs in children

, 2022
Better knowledge and understanding about drug desensitization is required in the pediatric population, since there is little literature available about it and the most pediatric desensitization protocols have been adapted from adult instructions.Aiming ...
Felix, Mara Morelo Rocha, da Cunha, Fernanda Sales, Ensina, Luis Felipe, Caubet, Jean-Christoph Roger J-P   +3 more
core   +1 more source

Importance of Desensitization for Autistic Children in Dental Practice [PDF]

, 2023
Objectives: Dental treatment in special needs patients, including children with autism, can be accomplished by reducing the behaviors that can reduce fear, as it has been demonstrated in other studies.
Eva Martínez Pérez, Alberto Adanero Velasco, Paloma Planells Del Pozo, Mónica Miegimolle Herrero, Adanero Velasco, Alberto, Martínez Pérez, Eva, Martínez Pérez, Eva María, Planells del Pozo, Paloma, Miegimolle Herrero, Mónica, Planells Delpozo, Paloma Nieves, Víctor Gómez Clemente, Gómez Clemente, Víctor   +11 more
core   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors

Cellular & Molecular Biology Letters
Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of receptor tyrosine ...
Dooti Kundu, Xiao Min, Shujie Wang, Lulu Peng, Xinru Tian, Mengling Wang, Kyeong-Man Kim   +6 more
doaj   +1 more source

Desensitization of thermal hyperemia in the skin is reproducible

, 2011
Local heating increases skin blood flow SkBF (thermal hyperemia). In a previous study, we reported that a first local thermal stimulus could attenuate the hyperemic response to a second one applied later on the same skin spot, a phenomenon that we termed
Liaudet, Lucas, Engelberger, R.P., Liaudet, L., Feihl, François, Waeber, B., Mazzolai, Lucia, BERNARD WAEBER, JOHANNA FRANTZ, Engelberger, Rolf Peter, ROLF PETER ENGELBERGER, LUCAS LIAUDET, Feihl, F., Frantz, Johanna, FRANÇOIS FEIHL, Mazzolai, L., LUCIA MAZZOLAI, Frantz, J., Waeber, Bernard   +17 more
core   +1 more source

Case report: Insulin desensitization as the only option for managing insulin allergy in a Sudanese patient

Frontiers in Allergy, 2023
IntroductionAllergic reactions to insulin have become very rare with the introduction of human insulin. Anaphylaxis is a life-threatening condition that results from immediate IgE-mediated hypersensitivity.
Rihan Said, Rayan Goda, Ihab B. Abdalrahman, Nahla H. H. Erwa, Nahla H. H. Erwa   +4 more
doaj   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Successful Interim Outcomes of Bortezomib Desensitization on Highly Sensitized Deceased Donor Kidney Transplant Waitlist Patients

Kidney Research and Clinical Practice, 2014
Highly sensitized (HS) patients seldom have chance to receive kidney transplant. To increase transplantation rate among those population, previous IV immunoglobulin and rituximab desensitization protocol showed good transplant conversion rate, but also ...
Jong Cheol Jeong, Hyuk Yong Kwon, Tai Yeon Koo, Hee Jung Jeon, Miyeun Han, Kook-Hwan Oh, Curie Ahn, Jaeseok Yang   +7 more
doaj   +1 more source