Results 21 to 30 of about 67,581 (257)

Platinum desensitization therapy and its impact on the prognosis of ovary high-grade serous adenocarcinoma: a real world-data

Frontiers in Immunology
BackgroundTo examine the value of five-step platinum desensitization therapy in epithelial ovarian cancerMethodsA retrospective study was conducted on the high-grade serous adenocarcinoma of the ovary (HGSAO) patients who developed a platinum allergy ...
Kemin Li, Kemin Li, Rutie Yin, Rutie Yin
doaj   +1 more source

Desensitization at the Interface [PDF]

ACS Chemical Biology, 2006
Normal brain function requires the faithful transmission and integration of information on a timescale of milliseconds, and this rapid signaling is mediated by cell membrane receptors that are ligand-gated ion channels. Fast excitatory transmission occurs when synaptically released glutamate opens channels in neighboring neurons, but these channels ...
openaire   +2 more sources

PERBEDAAN KEMAMPUAN PASTA GIGI DESENSITISASI KOMERSIAL DENGAN BAHAN AKTIF HIDROKSIAPATIT DAN NOVAMIN DALAM PENUTUPAN TUBULUS DENTIN DENGAN SCANNING ELECTRON MICROSCOPE

ODONTO: Dental Journal, 2016
Background: The use of commercial desensitization toothpaste is one of the way to treat dentine hypersensitivity. Desensitization tooth paste contains an active ingredient which is able to occlude the dentinal tubules to minimize the movement of fluid in
Hardita Bicevani Mulya, Andina Rizkia Putri Kusuma, Aning susilowati   +2 more
doaj   +1 more source

B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization

Frontiers in Medicine, 2021
Background: Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR).
David Cucchiari, David Cucchiari, Valeria Tubita, Jordi Rovira, Jordi Rovira, Maria J. Ramirez-Bajo, Maria J. Ramirez-Bajo, Elisenda Banon-Maneus, Elisenda Banon-Maneus, Marta Lazo-Rodriguez, Natalia Hierro-Garcia, Francesc E. Borràs, Francesc E. Borràs, Francesc E. Borràs, Pedro Ventura-Aguiar, Gastón J. Piñeiro, Jaume Martorell, Lluís Peri, Mireia Musquera, Alexandre Hertig, Federico Oppenheimer, Federico Oppenheimer, Josep M. Campistol, Josep M. Campistol, Josep M. Campistol, Fritz Diekmann, Fritz Diekmann, Fritz Diekmann, Ignacio Revuelta, Ignacio Revuelta, Ignacio Revuelta   +30 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus. [PDF]

PLoS Biology, 2008
The RCK-containing MthK channel undergoes two inactivation processes: activation-coupled desensitization and acid-induced inactivation. The acid inactivation is mediated by the C-terminal RCK domain assembly.
Mario Meng-Chiang Kuo, Innokentiy Maslennikov, Brent Molden, Senyon Choe   +3 more
doaj   +1 more source

Successful nedaplatin desensitization therapy in a patient with platinum-sensitive recurrent ovarian cancer: A case report and literature review

Gynecologic Oncology Reports, 2022
Desensitization protocols of platinum-based agents are recommended for patients with a history of hypersensitivity reaction (HSR). Herein, we report the first case of a successful desensitization therapy with nedaplatin after HSR to carboplatin and ...
Tetsuya Kokabu, Kohei Aoyama, Yosuke Tarumi, Hisashi Kataoka, Kaori Yoriki, Taisuke Mori   +5 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source