Results 91 to 100 of about 69,529 (271)

Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]

, 2014
Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin, Hell, Johannes Wilhelm, Matt, Lucas, Rogawski, Michael A   +3 more
core   +3 more sources

Testing the factor structure of the International Trauma Questionnaire in a sample of violence‐exposed women living in Northern Ireland

Journal of Traumatic Stress, EarlyView.
Abstract The International Trauma Questionnaire (ITQ) assesses posttraumatic stress disorder (PTSD) and the disturbances in self‐organization (DSO) aspect of complex PTSD (CPTSD) per the ICD‐11. This study examined the ITQ's factor structure among violence‐ or abuse‐exposed women in Northern Ireland, a region with a history of conflict (i.e., “the ...
Marcin Owczarek, Mark Shevlin, Julie‐Ann Jordan, Ngozi Anyadike‐Danes, Claire McCartan, Susan Lagdon   +5 more
wiley   +1 more source

Case Report: A novel approach to prevent chronic histiocytic intervillositis and recurrent pregnancy loss by targeting maternal alloimmunity

Frontiers in Immunology
Recurrent miscarriage is a distressing condition with limited therapeutic options. Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare inflammatory placental disorder characterized by maternal immune cell infiltration of the ...
Mathilde Gavillet, Mathilde Gavillet, Carole Gengler, Helene Legardeur, Monique Gannagé, Jardena Puder, Lydie Beauport, Alice Panchaud, Alice Panchaud, Alice Panchaud, Samuel Rotman, Denis Comte, David Baud, Dela Golshayan   +13 more
doaj   +1 more source

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets. [PDF]

, 2020
G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus ...
Benovic, Jeffrey, Brass, Lawrence F., Chen, Xi, Cooper, Matthew, DeHelian, Daniel, Goldfinger, Lawrence E., Gupta, Shuchi, Ma, Peisong, McKenzie, Steven E., Naik, Meghna U., Naik, Ulhas P., Stalker, Timothy J., Wurtzel, Jeremy G.T., Zhao, Xuefei   +13 more
core   +1 more source

Epileptic encephalopathy with spike‐and‐wave activation in sleep associated with Tatton–Brown–Rahman syndrome responsive to highly purified cannabidiol

Epileptic Disorders, EarlyView.
Anita N. Datta
wiley   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Efficacy And Safety of Acupoint Catgut Embedding for Perennial Allergic Rhinitis: Protocol for a Randomized Clinical Trial

JMIR Research Protocols
BackgroundAllergic rhinitis (AR) is a noninfectious chronic inflammatory disease of the nasal mucosa characterized mainly by itching, sneezing, nasal congestion, and rhinorrhea. It is mediated by immunoglobulin E (IgE).
Zijie Cai, ChunXue Meng, Fei Wang, ChunZhi Tang, Jing Zhang, Qian Zhang, Bin Guo   +6 more
doaj   +1 more source

Flooding

, 1999
Excerpt: A behavioral approach used in elimination of unwanted fears or phobias. In flooding the client either is directly exposed to or imagines highly frightening events in a protected setting.
Bufford, Rodger K.
core  

Capsaicin-Induced Ca2+ Influx and Constriction of the Middle Meningeal Artery [PDF]

, 2014
Research in the past on transient receptor potential cation channel subfamily V member 1 (TRPV1) has been limited to mainly nervous tissue TRPV1 because of the channel’s role in pain perception.
Koide, Masayo, Kotlikoff, Michael I., Manuelyan, Inessa, Shui, Bo, Syed, Arsalan U., Wellman, George C.   +5 more
core   +1 more source

“What Medical Management Should Be First Line for Bladder Storage Symptoms in NLUTD”—Pro Botox

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objectives Neurogenic lower urinary tract dysfunction (NLUTD) severely impairs patient quality of life (QoL). While oral medications are often first‐line treatments, their high failure rates and side effects limit their effectiveness. Thus, we argue for the use of intravesical botulinum toxin A (BoNT‐A) injections as a first‐line alternative ...
Vada Furlan, Alyssa Kobayashi, Zhina Sadeghi   +2 more
wiley   +1 more source