Results 11 to 20 of about 2,107,565 (334)

Tocilizumab Evaluation in HLA-Desensitization before Kidney Transplantation as an Add-On Therapy to Apheresis: The TETRA Study

Journal of Clinical Medicine, 2023
Background: Desensitization strategies improve access to transplantation in highly sensitized kidney transplant candidates. Tocilizumab could be a valuable addition to more traditional desensitization regimens.
T. Jouvé, Mélanie Daligault, Johan Noble, Florian Terrec, F. Imerzoukene, C. Dard, B. Bardy, P. Malvezzi, L. Rostaing   +8 more
semanticscholar   +1 more source

Desensitization in patients with hypersensitivity to platinum and taxane in gynecological cancers

Cancer Medicine, 2023
Exposure to paclitaxel and carboplatin has the risk of developing hypersensitivity reactions (HSRs), which could necessitate using less effective treatments to avoid anaphylaxis.
T. Zwimpfer, Kathrin Scherer, A. Schötzau, V. Heinzelmann-Schwarz, K. Hartmann, Marcus Vetter, Céline Montavon   +6 more
semanticscholar   +1 more source

Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial

BMC Pulmonary Medicine, 2023
Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp, Jane E. Reynolds, Sophia Tolbert, Sarah Campbell, Shannon Welby, Paige Morkrid   +5 more
semanticscholar   +1 more source

ASA Allergy and Desensitization Protocols in the Management of CAD: A Review of Literature

Journal of Clinical Medicine, 2023
Acetylsalicylic acid (ASA) hypersensitivity still represents one of the major deals for patients with atherosclerotic cardiovascular disease (ASHD), especially for those requiring percutaneous coronary interventions in the absence of validated ...
M. Verdoia, R. Gioscia, M. Nardin, G. De Luca   +3 more
semanticscholar   +1 more source

β-Adrenergic Receptor Desensitization/Down-Regulation in Heart Failure: A Friend or Foe?

Frontiers in Cardiovascular Medicine, 2022
Cardiac sympathetic activation, mediated by β-adrenergic receptors (β-ARs), normally increases cardiac contraction and relaxation. Accomplishing this task requires a physiological, concerted Ca2+ signaling, being able to increase Ca2+ release from ...
Abrahim Mahmood, Kinza Ahmed, Youhua Zhang   +2 more
semanticscholar   +1 more source

Desensitization for the prevention of drug hypersensitivity reactions

The Korean Journal of Internal Medicine, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Sung-Yoon Kang, J. Seo, H. Kang
semanticscholar   +1 more source

Toxicity management and efficacy of carboplatin desensitization therapy for recurrent epithelial ovarian carcinoma: A real-world study

Medicine, 2022
Epithelial Ovarian cancer (EOC) is the most lethal gynecologic cancer worldwide. Carboplatin (CP) is the main chemotherapeutic agent in the treatment of ovarian cancer.
N. Paksoy, N. Khanmammadov, I. Dogan, F. Ferhatoğlu, Anıl Yıldız, N. Ak, A. Aydıner   +6 more
semanticscholar   +1 more source

C-Reactive Protein (CRP) Blocks the Desensitization of Agonistic Stimulated G Protein Coupled Receptors (GPCRs) in Neonatal Rat Cardiomyocytes

Journal of Clinical Medicine, 2022
Recently, C-reactive protein (CRP) was shown to affect intracellular calcium signaling and blood pressure in vitro and in vivo, respectively. The aim of the present study was to further investigate if a direct effect on G-protein coupled receptor (GPCR ...
G. Wallukat, S. Mattecka, K. Wenzel, W. Schrödl, B. Vogt, P. Brunner, A. Sheriff, R. Kunze   +7 more
semanticscholar   +1 more source

Tocilizumab and Desensitization in Kidney Transplant Candidates: Personal Experience and Literature Review

Journal of Clinical Medicine, 2021
Desensitization (DES) allows kidney transplantation for highly HLA-sensitized subjects. Due to the central role of IL-6 in the immunological response, tocilizumab may improve DES efficacy.
Jules Weinhard, Johan Noble, T. Jouvé, P. Malvezzi, L. Rostaing   +4 more
semanticscholar   +1 more source

Management of chronic rhinosinusitis with nasal polyps in Samter triad by low-dose ASA desensitization or dupilumab

Medicine, 2021
Samter triad is a chronic condition where patients suffer from intolerance to aspirin, recurring nasal polyposis and bronchial asthma. Causative treatment is often hard.
M. Bertlich, F. Ihler, I. Bertlich, B. Weiss, M. Gröger, F. Haubner   +5 more
semanticscholar   +1 more source