Results 21 to 30 of about 2,288,448 (331)
Current Oncology, 2023 Background: The landscape of systemic therapies for advanced non-melanoma skin cancers has been revolutionized by the advent of immunotherapy. Cemiplimab is the only immune checkpoint inhibitor (ICI) approved by the European Medicine Agency for recurrent/
Marco Banini +10 more
doaj +1 more source
Frontiers in Medicine, 2021 Recipient sensitization is a major risk factor of antibody-mediated rejection (ABMR) and inferior graft survival. The predictive effect of solid-phase human leukocyte antigen antibody testing and flow cytometry crossmatch (FCXM) in the era of ...
K. Osickova +9 more
semanticscholar +1 more source
Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chen, Chao-Yin +3 more
core +8 more sources
Improving adherence to PAP therapy: A brief PAP coaching intervention for health care providers
PEC Innovation, 2023 Objectives: To evaluate a training program for non-specialist health care providers in a brief coaching intervention to improve positive airway pressure (PAP) usage in Veterans with sleep apnea.
Ken He +6 more
doaj +1 more source
Tocilizumab Trough Levels Variability in Kidney-Transplant Candidates Undergoing Desensitization
Journal of Clinical Medicine, 2021 The presence of anti-HLA antibodies is an increasing challenge in kidney transplantation. Tocilizumab (TCZ), a monoclonal antibody targeting the interleukin-6 receptor (IL-6R), has been proposed to complement conventional desensitization therapy.
Aurélie Truffot +7 more
semanticscholar +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2020 Kidney transplantation has indisputably revamped renal medicine and restored hope among patients coming across fatal end-stage renal disease. However, sensitization of human leukocyte antigen (HLA) triggers extensive immunological fences to successful ...
Muhammad Tassaduq Khan +5 more
doaj +1 more source
Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity. [PDF]
, 2017 Membrane potential controls the response of the M2 muscarinic receptor to its ligands. Membrane hyperpolarization increases response to the full agonist acetylcholine (ACh) while decreasing response to the partial agonist pilocarpine.
Chen, I-Shan +2 more
core +1 more source
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
, 2014 Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
The Predominant Role of Arrestin3 in General GPCR Desensitization in Platelets
Journal of Clinical Medicine, 2021 Arrestins in concert with GPCR kinases (GRKs) function in G protein-coupled receptor (GPCR) desensitization in various cells. Therefore, we characterized the functional differences of arrestin3 versus arrestin2 in the regulation of GPCR signaling and its
P. Chaudhary, Sanggu Kim, Soochong Kim
semanticscholar +1 more source
Oral immunotherapy for food allergy: Translation from studies to clinical practice?
World Allergy Organization Journal, 2023 Oral immunotherapy (OIT) is now recognized as an alternative active treatment to strict food avoidance in certain patients with IgE-mediated food allergy. Studies have confirmed the efficacy of OIT to desensitize children with allergy to cow's milk, eggs,
Guillaume Pouessel, MD +1 more
doaj +1 more source