Results 21 to 30 of about 2,107,565 (334)

B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization

Frontiers in Medicine, 2021
Background: Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR).
D. Cucchiari, Valeria Tubita, J. Rovira, M. Ramirez-Bajo, E. Bañon-maneus, M. Lazo-Rodríguez, Natalia Hierro-Garcia, F. Borràs, P. Ventura-Aguiar, Gaston J. Piñeiro, J. Martorell., L. Peri, M. Musquera, A. Hertig, F. Oppenheimer, J. Campistol, F. Diekmann, I. Revuelta   +17 more
semanticscholar   +1 more source

Predictive Potential of Flow Cytometry Crossmatching in Deceased Donor Kidney Transplant Recipients Subjected to Peritransplant Desensitization

Frontiers in Medicine, 2021
Recipient sensitization is a major risk factor of antibody-mediated rejection (ABMR) and inferior graft survival. The predictive effect of solid-phase human leukocyte antigen antibody testing and flow cytometry crossmatch (FCXM) in the era of ...
K. Osickova, P. Hruba, Katerina Kabrtova, J. Kléma, J. Maluskova, A. Slavcev, J. Slatinská, T. Marada, G. Böhmig, O. Viklicky   +9 more
semanticscholar   +1 more source

The Predominant Role of Arrestin3 in General GPCR Desensitization in Platelets

Journal of Clinical Medicine, 2021
Arrestins in concert with GPCR kinases (GRKs) function in G protein-coupled receptor (GPCR) desensitization in various cells. Therefore, we characterized the functional differences of arrestin3 versus arrestin2 in the regulation of GPCR signaling and its
P. Chaudhary, Sanggu Kim, Soochong Kim
semanticscholar   +1 more source

Successful desensitization and kidney transplantation in the presence of donor-specific anti-human leukocyte antigen antibodies in kidney transplant recipients

Saudi Journal of Kidney Diseases and Transplantation, 2020
Kidney transplantation has indisputably revamped renal medicine and restored hope among patients coming across fatal end-stage renal disease. However, sensitization of human leukocyte antigen (HLA) triggers extensive immunological fences to successful ...
Muhammad Tassaduq Khan, Rashid bin Hamid, Sabahat Sarfaraz, Naranjan Lal, Jaleel Ahmed, Shobha Luxmi   +5 more
doaj   +1 more source

Tocilizumab Trough Levels Variability in Kidney-Transplant Candidates Undergoing Desensitization

Journal of Clinical Medicine, 2021
The presence of anti-HLA antibodies is an increasing challenge in kidney transplantation. Tocilizumab (TCZ), a monoclonal antibody targeting the interleukin-6 receptor (IL-6R), has been proposed to complement conventional desensitization therapy.
A. Truffot, T. Jouvé, Johan Noble, B. Bardy, P. Malvezzi, L. Rostaing, F. Stanke-Labesque, E. Gautier‐Veyret   +7 more
semanticscholar   +1 more source

Oral immunotherapy for food allergy: Translation from studies to clinical practice?

World Allergy Organization Journal, 2023
Oral immunotherapy (OIT) is now recognized as an alternative active treatment to strict food avoidance in certain patients with IgE-mediated food allergy. Studies have confirmed the efficacy of OIT to desensitize children with allergy to cow's milk, eggs,
Guillaume Pouessel, MD, Guillaume Lezmi, MD, PhD   +1 more
doaj   +1 more source

The future outlook on allergen immunotherapy in children: 2018 and beyond. [PDF]

, 2018
Allergen immunotherapy (AIT) is the only currently available immune-modifying and aetiological treatment for patients suffering from IgE-mediated diseases.
Arasi S, Corsello G, Pajno GB, Villani A
core   +2 more sources

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

Hypersensitivity Reactions to Monoclonal Antibodies in Children

Medicina, 2020
Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases.
Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli   +11 more
doaj   +1 more source

Interdisciplinary Healthcare Team Experience of Carboplatin and Oxaliplatin Desensitizations in a Tertiary Referral University Hospital

Journal of Asthma and Allergy, 2023
Ceyda Tunakan Dalgic,1 Asuman Camyar,1 Nihal Mete Gokmen,1 Sukriye Miray Kilincer Bozgul,2 Mehmet Zuhuri Arun,3 Zehra Tuba Karaman,2 Elif Ertuna3 1Department of Internal Medicine, Division of Allergy and Immunology, Faculty of Medicine, Ege University ...
Tunakan Dalgic C, Camyar A, Mete Gokmen N, Kilincer Bozgul SM, Arun MZ, Karaman ZT, Ertuna E   +6 more
doaj