Results 81 to 90 of about 4,201,253 (313)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
¿La disponibilidad del recurso trófico afecta la selección de grietas por Octomys mimax en el Desierto del Monte? [PDF]
, 2015 Rocky habitats have a particular microclimate and a highly complex structure, providing sites that mammals can use as dens or as nesting sites to raise their young.
Campos, Valeria Evelin +4 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2022 Currently, climate change is causing changes in the desert vegetation's biodiversity. This has led to a significant reduction in the species composition of desert grassland vegetation, and the results of the investigates shows that in pasture reserves the composition of the species may increase into 4-6 by forming micro ...
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Masdar - The Sustainable Desert City: A Theoretical Mirage or A Realistic [PDF]
, 2010 Masdar City, currently being developed in Abu Dhabi and designed by Foster + Partners, a high-profile British firm of architects, sets a groundbreaking example of a new breed of eco-cities. The city’s birth has taken on an environmental stance. Having
Tang, Gabriel
core
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Leaf-surface wax of desert plants as a potential lubricant additive
, 2015 Using an MFT-R4000 tester at room temperature, the leaf-surface wax of two desert plants, Ammopiptanthus mongolicus (AM) and Reaumuria soongorica (RS), was extracted and evaluated for its potential as a lubricant additive in polyalphaolefin (PAO) for ...
Yanqiu Xia +3 more
semanticscholar +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Photosynthetic Organs of Desert Plants [PDF]
BioScience, 1998 M any species of plants and animals are remarkably adapted to live in hot, dry deserts, where annual rainfall is extremely low and organisms must cope with long drought. The natural history and environmental biology of desert organisms-how they manage life under such a dry regime-is of particular interest.
openaire +1 more source