Results 111 to 120 of about 23,284,066 (340)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
To Design a Designer To Design Designs
, 2008 PUBLISHED This paper reports on the implementation of a new project based design course at first year level of an engineering degree programme. The project, carried out in groups of six, uses the design and construction of a ?Mangonel?, or catapult, as its primary task.
openaire +1 more source
Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope [PDF]
, 2010 Bruno E. Correia +17 more
openalex +1 more source
Creating and Operating National Agricultural Information Exchange Points [PDF]
, 2007 WorldAgInfo Project Solution Scenario 4: Technologies and Information Exchange Systems. Based on the deliberations of participant groups in Workshop 1, the WorldAgInfo Design Team drafted a problems and solutions summary document (available within ...
World Ag Info Project Design Team
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Developing Online and Offline Textbook Collections to Support Agricultural Curricula [PDF]
, 2007 WorldAgInfo Project Solution Scenario 7: Preparing Universities for the New Agriculture. Based on the deliberations of participant groups in Workshop 1, the WorldAgInfo Design Team drafted a problems and solutions summary document (available within ...
World Ag Info Project Design Team
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Investigation of main characteristics of frequency multipliers in the range of 120-220 GHz
Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019 The features of the design and the operation principle of frequency doublers in range 120-220 GHz are considered. The results of input and output power measurements of frequency doublers are given, the values of them efficiency factors are calculated.
M. A. Borovskaya +4 more
doaj
And, 2020 This thesis project, whose speaker was Prof. Francesca Tosi (Unifi), aims to involve the way makers design applied to a bicycle brand business.
Andrea Grandi
doaj