Results 61 to 70 of about 729,523 (281)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A Short Review of Advancements in Additive Manufacturing of Cemented Carbides
CrystalsCemented carbides, renowned for their exceptional strength, hardness, elastic modulus, wear resistance, corrosion resistance, low coefficient of thermal expansion, and chemical stability, have long been indispensable tooling materials in metal cutting ...
Zhe Zhao +10 more
doaj +1 more source
A Toolbox for Designing 3D‐Printing‐Ready Pneumatic Circuits for Controlling Soft Robots
Advanced Intelligent Systems, 2023 The robotics field has witnessed a rapid increase in the popularity of soft pneumatic robots due to their adaptability to unstructured environments and safe human–robot interaction.
Sihan Wang +4 more
doaj +1 more source
MIDAS: Automated Approach to Design Microwave Integrated Inductors and Transformers on Silicon [PDF]
, 2013 The design of modern radiofrequency integrated circuits on silicon operating at microwave and millimeter-waves requires the integration of several spiral inductors and transformers that are not commonly available in the process design-kits of the ...
Alimenti, F. +4 more
core +1 more source
Photonics design tool for advanced CMOS nodes
, 2015 Recently, the authors have demonstrated large-scale integrated systems with several million transistors and hundreds of photonic elements. Yielding such large-scale integrated systems requires a design-for-manufacture rigour that is embodied in the 10 ...
Alloatti, Luca +4 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
From design to design automation [PDF]
Proceedings of the 2014 on International symposium on physical design, 2014 I had the pleasure to work at the Xerox Palo Alto Research Center (PARC) as a summer intern in 1987 with Dr. Bryan Preas. One of the many valuable lessons that I learned through that summer internship is that as a researcher in electronic design automation (EDA), there is a tremendous value to be had from an involvement in VLSI circuit and system ...
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Tracking Control of A Balancing Robot – A Model-Based Approach
Archive of Mechanical Engineering, 2014 This paper presents a control concept for a single-axle mobile robot moving on the horizontal plane. A mathematical model of the nonholonomic mechanical system is derived using Hamel's equations of motion.
Zaiczek Tobias, Franke Matthias
doaj +1 more source
Many-Tier Vertical GAAFET (V-FET) for Ultra-Miniaturized Standard Cell Designs Beyond 5 nm
IEEE Access, 2020 The GAAFET (gate-all-around FET) is expected to replace FinFETs in future nodes due to its excellent channel controllability. It is also expected to be an impressive device due to its horizontal or vertical transistor structures. Vertical GAAFETs (V-FETs)
Taigon Song
doaj +1 more source