Results 71 to 80 of about 729,523 (281)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Enhancing lower-limb rehabilitation: a scoping review of augmented reality environment

Journal of NeuroEngineering and Rehabilitation
Background Lower-limb rehabilitation is crucial for restoring motor function in individuals with physical impairments; however, traditional rehabilitation approaches often encounter challenges such as limited resources and reduced patient motivation ...
Yuanyuan Liu, Qiong Zhang, Weiyi Li
doaj   +1 more source

Evaluating the Effectiveness of Autorouting in PCB Design

Engineering Proceedings
This research aims to determine an optimized set of parameters for Altium Designer’s built-in autorouting function when applied on two- or more-layer printed circuit board (PCB) designs.
Péter Gulyás
doaj   +1 more source

Design and Optimization of a Low-Resonant-Frequency Piezoelectric MEMS Energy Harvester Based on Artificial Intelligence

Proceedings, 2018
In this study we propose a piezoelectric MEMS vibration energy harvester with the capability of oscillating at low (i.e., less than 200 Hz) resonant frequency. The mechanical structure of the proposed harvester is comprised of a doubly clamped cantilever
Seyedfakhreddin Nabavi, Lihong Zhang
doaj   +1 more source

Programming Escherichia coli to function as a digital display

Molecular Systems Biology, 2020
Synthetic genetic circuits offer the potential to wield computational control over biology, but their complexity is limited by the accuracy of mathematical models.
Jonghyeon Shin, Shuyi Zhang, Bryan S Der, Alec AK Nielsen, Christopher A Voigt   +4 more
doaj   +1 more source

Banning design automation software implementation [PDF]

The research is reported for developing a system of computer programs to aid engineering in the design, fabrication, and testing of large scale integrated circuits, hybrid circuits, and printed circuit boards.
Kuehlthau, R. L.
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

The use of artificial intelligence in adapting process of UI design system for end customer requirements

Радіоелектронні і комп'ютерні системи
This paper demonstrates an approach for developing an AI-based UI design system to improve a company white labeling (aka rebranding) process. This is the process of removing a product or service's original branding and replacing it with the branding of ...
Kyrylo Polishchuk, Eugene Brezhniev
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source