Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Design concept for bolted Glass
Challenging Glass Conference Proceedings, 2010 For the design of load carrying glazing structures the connection technique plays an important role, as e.g. there are significant stress concentrations in the vicinity of holes that are subject to a point-like support of glass panes.
M. Baitinger, M. Feldmann
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Molecular Design Concept for Enhancement Charge Carrier Mobility in OFETs: A Review. [PDF]
Materials (Basel), 2023 Zhou Y, Zhang K, Chen Z, Zhang H.
europepmc +1 more source
Heinz Isler: shells for two churches [PDF]
, 2011 This paper describes the concept, design and realisation of two churches where Heinz Isler (1926-2009) was responsible for the structural design and in one case also for the architectural concept. One example, the Heilig Geist Kirche (Holy Spirit Church)
Chilton, JC
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Application of the Quality by Design Concept (QbD) in the Development of Hydrogel-Based Drug Delivery Systems. [PDF]
Polymers (Basel), 2023 Mohseni-Motlagh SF +3 more
europepmc +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
A novel MCDM approach for design concept evaluation based on interval-valued picture fuzzy sets. [PDF]
PLoS One, 2023 Ma Q, Sun H, Chen Z, Tan Y.
europepmc +1 more source
Design and construction of a hydrogen energy system covering low-carbon production and highly efficient storage based on the concept of green hydrogen science [PDF]
, 2013 Zaiku Xie, Zhonghao Jin, YangDong WANG
openalex +1 more source