Results 131 to 140 of about 4,347,183 (334)

Down to the Bone: A Novel Bio-Inspired Design Concept. [PDF]

Materials (Basel), 2021
Buccino F, Aiazzi I, Casto A, Liu B, Sbarra MC, Ziarelli G, Vergani LM, Bagherifard S.   +7 more
europepmc   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Changing Human Factor in the Concept of Design and Changing Inclusive Design Approaches

IDA: International Design and Art Journal, 2020
The starting point of the design concept is considered concurrent with the history of humanity. In designing, which directly depends on humans with its existence, all the products, both abstract and concrete, are addressed to meet the needs of human ...
Zeynep ACIRLI, Özge KANDEMİR
doaj  

Design as a Literary Concept? [PDF]

Slovenska Literatura, 2014
In relation to his book Černá kočka aneb Subjekt znalce v myšlení o literatuře a jeho komunikační strategie (A Black Cat or The Subject of the Expert in Literary Thinking and His Communication Strategies, Praha, Academia 2012), the writer of the article ...
Pavel Janoušek
doaj  

A Novel Design Concept of Cemented Paste Backfill (CPB) Materials: Biobjective Optimization Approach by Applying an Evolved Random Forest Model. [PDF]

Materials (Basel), 2022
He Y, Cheng Y, Ma M, Li F, Song Y, Liu L, Wang X, Huang J.   +7 more
europepmc   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

EVTOL concept design

, 2023
Objectius de Desenvolupament Sostenible::15 - Vida d'Ecosistemes ...
openaire   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

KNOWLEDGE REPRESENTATION OF SECURITY DESIGN PATTERN LANDSCAPE USING FORMAL CONCEPT ANALYSIS [PDF]

Journal of Engineering Science and Technology, 2017
Security design patterns are proven solutions to recurring security problems. They are classified into various categories, each containing a set of attributes.
POONAM S. PONDE, SHAILAJA C. SHIRWAIKAR, VILAS S. KHARAT   +2 more
doaj  

Wi-Fi Access Point Design Concept Targeting Indoor Positioning for Smartphones and IoT. [PDF]

Sensors (Basel), 2022
El-Gendy MS, Ashraf I, El-Hennawey S.
europepmc   +1 more source