Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Changing Human Factor in the Concept of Design and Changing Inclusive Design Approaches
IDA: International Design and Art Journal, 2020 The starting point of the design concept is considered concurrent with the history of humanity. In designing, which directly depends on humans with its existence, all the products, both abstract and concrete, are addressed to meet the needs of human ...
Zeynep ACIRLI, Özge KANDEMİR
doaj
Influence of a new abutment design concept on the biomechanics of peri-implant bone, implant components, and microgap formation: a finite element analysis. [PDF]
BMC Oral Health, 2023 Nie H +5 more
europepmc +1 more source
Is spatial intelligibility critical to the design of largescale virtual environments? [PDF]
, 2002 This paper discusses the concept of 'intelligibility', a concept usually attributed to the design of real-world environments and suggests how it might be applied to the construction of virtual environments.
Conroy-Dalton, R
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Reliability Risk Evaluation during the Conceptual Design Phase
Acta Polytechnica, 2006 I (Relative Reliability Risk Index) is calculated and the idea of concept functionality graphs is presented. This method is applied on the example of seat suspensions for an off highway vehicle and the results are discussed.
G. Mamtani, G. Green
doaj
SymPET, a waveform digitizing "System on Chip" for ultra-high resolution TOF PET: design concept and preliminary studies. [PDF]
IEEE Nucl Sci Symp Conf Rec (1997), 2022 Flood K +9 more
europepmc +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
AI-Assisted Design Concept Exploration Through Character Space Construction. [PDF]
Front Psychol, 2021 Sano S, Yamada S.
europepmc +1 more source
Visual Concept of Game Heroic Education Based on Player-Centered Design
, 2022 Amirul Mu’minin, Intan Rizky Mutiaz
openalex +1 more source