Results 141 to 150 of about 4,347,183 (334)

The Revitalization Concept of “Pramuka Penggalang” in The Digital Game Design [PDF]

open access: yes, 2019
The scout activity is a non-formal education in environments such as school and family. Generally, it held in the outdoors as an attractive place, challenging, creative, innovative, and fun.
Budiman, A. (Arief)   +1 more
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Structural durability assessment of welded offshore K-nodes by different local design concepts [PDF]

open access: yesFracture and Structural Integrity, 2009
The structural durability design of complex welded structures should not rely only on one single design method but should apply different methods for assuring the reliability of the assessment.
C.M. Sonsino
doaj  

Design concept for the Flight Telerobotic Servicer (FITS) [PDF]

open access: yes
NASA has just completed an in-house Phase B Study (one of three studies) for the preliminary definition of a teleoperated robotic device that will be used on the National Space Transportation System (NSTS) and the Space Station to assist the astronauts ...
Andary, J. F.   +2 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Reliability Risk Evaluation during the Conceptual Design Phase

open access: yesActa Polytechnica, 2006
I (Relative Reliability Risk Index) is calculated and the idea of concept functionality graphs is presented.  This method is applied on the example of seat suspensions for an off highway vehicle and the results are discussed.
G. Mamtani, G. Green
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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