Results 151 to 160 of about 4,753,099 (348)

Solution Concept Modeling and Evaluation Based on Function-Structure and Behavior Approach in the Context of Inventive Design

, 2021
Muhammad Irshad Yehya, Amadou Coulibaly, Hicham Chibane, Rémy Houssin   +3 more
openalex   +2 more sources

Comics, robots, fashion and programming: outlining the concept of actDresses [PDF]

, 2009
This paper concerns the design of physical languages for controlling and programming robotic consumer products. For this purpose we explore basic theories of semiotics represented in the two separate fields of comics and fashion, and how these could be ...
Fernaeus, Ylva, Jacobsson, Mattias
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A Novel Design Concept of Cemented Paste Backfill (CPB) Materials: Biobjective Optimization Approach by Applying an Evolved Random Forest Model. [PDF]

Materials (Basel), 2022
He Y, Cheng Y, Ma M, Li F, Song Y, Liu L, Wang X, Huang J.   +7 more
europepmc   +1 more source

Design of customized soft‐tissue substitutes for posterior single‐tooth defects: A proof‐of‐concept in‐vitro study [PDF]

, 2021
Yue Sun, Yu Tao, Malin Strasding, Xinran Liu, Felix Burkhardt, Birgit Schäfer, Irena Sailer, Dobrila Nešić   +7 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Failure Analysis and Prevention of Extraction Column for Methyl Methacrylate Production: Application of the 'Safety Design' Concept. [PDF]

Materials (Basel), 2021
Wang SH, Gong Y, Tong Q, Yang XL, Shen JH, Yang ZG.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Fully Depleted Monolithic Active Microstrip Sensors: TCAD Simulation Study of an Innovative Design Concept. [PDF]

Sensors (Basel), 2021
De Cilladi L, Corradino T, Dalla Betta GF, Neubüser C, Pancheri L.   +4 more
europepmc   +1 more source