Results 61 to 70 of about 4,605,170 (283)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
IEEE Access, 2018 This paper describes a novel hackathon-style system engineering process and its value as an agile approach to the rapid generation and development of early design concepts of complex engineered products-in this case a future aircraft.
S. Saravi +8 more
doaj +1 more source
The Journal of Engineering, 2020 In order to solve the problems of low production efficiency, poor quality of blanks, high labour intensity and inability to meet the market demand with the manual gypsum mould, a novel design of the gypsum mould to be applied into the automatic ...
Gu Lizhi +7 more
doaj +1 more source
Issues Affecting Security Design Pattern Engineering [PDF]
, 2013 Security Design Patterns present the tried and tested design decisions made by security engineers within a well documented format. Patterns allow for complex security concepts, and mechanisms, to be expressed such that non domain experts can make use of ...
de Muijnck-Hughes, Jan, Duncan, Ishbel
core
Functionally heterogeneous porous scaffold design for tissue engineering [PDF]
, 2012 Most of the current tissue scaffolds are mainly designed with homogeneous porosity which does not represent the spatial heterogeneity found in actual tissues.
Khoda, AKM B. +2 more
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
A service oriented architecture for engineering design [PDF]
, 2004 Decision making in engineering design can be effectively addressed by using genetic algorithms to solve multi-objective problems. These multi-objective genetic algorithms (MOGAs) are well suited to implementation in a Service Oriented Architecture ...
Fleming, P.J., Shenfield, A.
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Diagnostic systems in DEMO: engineering design issues
, 2014 The diagnostic systems of DEMO that are mounted on or near the torus, whether intended for the monitoring and control functions of the engineering aspects or the physics behaviour of the machine, will have to be designed to suit the hostile nuclear ...
Todd, T N
core +1 more source
Synthetic biology—putting engineering into biology [PDF]
, 2006 Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core +1 more source