Results 101 to 110 of about 7,219,960 (314)

The 'what' and 'how' of learning in design, invited paper [PDF]

, 1997
Previous experiences hold a wealth of knowledge which we often take for granted and use unknowingly through our every day working lives. In design, those experiences can play a crucial role in the success or failure of a design project, having a great ...
Duffy, Alex H. B.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Knowledge practices in design: The role of visual representations as 'epistemic objects' [PDF]

, 2009
We use a detailed study of the knowledge work around visual representations to draw attention to the multidimensional nature of `objects'. Objects are variously described in the literatures as relatively stable or in flux; as abstract or concrete; and as
Austin, Robert, Beck, Ulrich, Boris Ewenstein, Edward Cullinan Architects, Edward Cullinan Architects, Edward Cullinan Architects, Elkins, James, Giddens, Anthony, Glaser, Barney G., Hale, Jonathan, Heath, Christian, Henderson, Katherine, Jennifer Whyte, Latour, Bruno, Law, John, Law, John, Mol, Annemarie, Orr, Julian, Powell, Kenneth, Rheinberger, Hans-Jörg, Schatzki, Theodore R., Schön, D.A., Strati, A., Strauss, Anselm L., Vincenti, Walter G.   +24 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Integrating BWM and modified VIKOR for age-friendly community park assessment in the context of mental health

Frontiers in Medicine
BackgroundLate-life depression is a growing public health challenge in aging societies. Community parks are increasingly recognized as protective environments, yet evidence on which specific attributes most effectively alleviate depression among older ...
Zhi-Hao Zhang, Yi-Fan Zhang, Cheng-Cheong Lei   +2 more
doaj   +1 more source

Design and Development of Iranian Institutional Repositories Integrated Search (IRIS) Portal

Iranian Journal of Information Processing & Management, 2021
The purpose of this research is to design and develop an integrated open portal for searching and retrieving information of institutional repositories of universities, and higher education and research institutes in Iran.
Bahareh Pahlevanzadeh, Mahdi Zahedi Nooghabi   +1 more
doaj  

Representation and matching of knowledge to design digital systems [PDF]

, 1988
A knowledge-based expert system is described that provides an approach to solve a problem requiring an expert with considerable domain expertise and facts about available digital hardware building blocks.
Jones, J. U., Shiva, S. G.
core   +1 more source

Semantic data mining and linked data for a recommender system in the AEC industry [PDF]

, 2019
Even though it can provide design teams with valuable performance insights and enhance decision-making, monitored building data is rarely reused in an effective feedback loop from operation to design. Data mining allows users to obtain such insights from
Jensen, Rasmus Lund, Pauwels, Pieter, Petrova, Ekaterina, Svidt, Kjeld   +3 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Perception and argumentation in the LK-99 superconductivity controversy: a sentiment and argument mining analysis

Scientific Reports
The announcement of LK-99 as a potential room-temperature, ambient-pressure superconductor sparked widespread debate across both traditional news outlets and social media platforms.
Eunhye Kim, Wei Luo, Hunkoog Jho
doaj   +1 more source