Results 61 to 70 of about 7,219,960 (314)

Integrating inquiry-based learning into architectural design studios: toward a flexible framework

Journal of Asian Architecture and Building Engineering
Since the 2010s, architectural education has faced increasing criticism, highlighting the marginalization of research and theoretical inquiry within design studios dominated by visual and representational approaches.
Neslinur Hızlı Erkılıç
doaj   +1 more source

Workshop design for enhancing the appropriateness of idea generation using analogical thinking

International Journal of Innovation Studies, 2017
As technologies advance and replace human labor in a variety of settings, we focus our attention on human creativity for generating new ideas. Business organizations, more than ever, recognize that they need employees who think creatively to maintain ...
Eunyoung Kim
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Supporting early robust design for different levels of specific design knowledge: an adaptive method for modeling with the Embodiment Function Relation and Tolerance model

Design Science
Early robust design (RD) can lead to significant cost savings in the later stages of product development. In order to design systems that are insensitive to various sources of deviation in the early stages, specific design knowledge (SDK) plays a crucial
Jiahang Li, Dennis Horber, Patric Grauberger, Stefan Goetz, Sandro Wartzack, Sven Matthiesen   +5 more
doaj   +1 more source

Knowledge-Based Design

, 2013
The chapter “Knowledge-Based Design”, covers the use of template models, integrated calculation and simulation procedures, and automated routines to support product design. Knowledge-based design enables the collection, storage and re-use of expert knowledge, as well as the subsequent integration of know-how into development processes.
Mario Hirz, Wilhelm Dietrich, Anton Gfrerrer, Johann Lang   +3 more
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

How do we know in design? Exploring knowledge and inquiry in architectural design

Journal of Architecture and Urbanism
This paper examines the intricate relationship that exists between the field of architecture and the role that research can play in it, by describing how this relationship has manifested itself in academic environments over the past two decades.
Stefano Corbo
doaj   +1 more source

The interior design of [free] knowledge [PDF]

Journal of Cultural Economy, 2014
What would a ‘free knowledge bank’ look like if it were to be designed as an architectural object? The challenge was posed by El Ranchito, a curatorial project based at Madrid’s contemporary art centre, Matadero, to the art and architectural collective Zoohaus in 2011.
Corsín Jiménez, Alberto, Estalella, Adolfo, Zoohaus   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Influence of Tramp Elements on Phase Transformations, Microstructure and Hardness of a 0.3 wt.%C Low-Alloyed Steel

Metals
Decarbonizing the steel industry relies on a transition from carbon-intensive blast furnace technology to scrap-based secondary steelmaking using electric arc furnaces.
Marek Gocnik, Lukas Hatzenbichler, Michael Meindlhumer, Phillip Haslberger, Matthew Galler, Andreas Stark, Claes-Olof A. Olsson, Jozef Keckes, Ronald Schnitzer   +8 more
doaj   +1 more source