Results 101 to 110 of about 3,978,056 (320)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimal development of apoptotic cells-mimicking liposomes targeting macrophages

Journal of Nanobiotechnology
Macrophages are multifunctional innate immune cells that play indispensable roles in homeostasis, tissue repair, and immune regulation. However, dysregulated activation of macrophages is implicated in the pathogenesis of various human disorders, making ...
Li Zhang, Yujiao Li, Xing Liu, Xiaolu He, Jieyu Zhang, Jun Zhou, Youbei Qiao, Hong Wu, Fangfang Sun, Qing Zhou   +9 more
doaj   +1 more source

Design of an organic farming crop rotation experiment [PDF]

, 2000
A field experiment is conducted which focuses on crop rotations for cereal production in organic farming. The objective of the experiment is to explore the possibilities for both short-term and long-term increases in organic cereal production through ...
Askegaard, Margrethe, Olesen, Jørgen E., Rasmussen, Ilse Ankær   +2 more
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Designing an Autonomous Underwater Vehicle hull shape with direct approach

نشریه مهندسی دریا, 2018
Hydrodynamic design of the exterior hull shape is a main step of body shape design. The effective parameters in this process include the length of the nose and tail, the blunt sections of nose and tail as well as the profiles of the nose and the tail. In
Majid Alijani, Nowrouz Mohammad Nouri, Marhamat Zeinali   +2 more
doaj  

Electrical design of payload G-534: The Pool Boiling Experiment [PDF]

Payload G-534, the Pool Boiling Experiment (PBE), is a Get Away Special that is scheduled to fly on the shuttle in 1992. This paper will give a brief overall description of the experiment with the main discussion being the electrical design with a ...
Francisco, David R.
core   +1 more source

Catalytic surface effects on space thermal protection system during Earth entry of flights STS-2 through STS-5 [PDF]

, 1983
An on going orbiter experiment catalytic surface effects experiment being conducted on the Space Shuttle is discussed. The catalytic surface effects experiment was peformed on four of the five flights of Columbia.
Lanfranco, M. J., Rakich, J. V., Stewart, D. A.   +2 more
core   +1 more source

The ArDM project: a Dark Matter Direct Detection Experiment based on Liquid Argon

, 2006
The Dark Matter part of the universe presumably consists of WIMPs (Weakly Interacting Massive Particles). The ArDM project aims at measuring signals induced by WIMPs in a liquid argon detector.
, André Rubbia, André Rubbia, André Rubbia, Lilian Kaufmann   +4 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source