Results 31 to 40 of about 1,282,652 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research on wind tunnel test of low-speed characteristics optimization in Kink area of transport aircraft wings

Hangkong gongcheng jinzhan
For conventionally laid out civil transport aircraft in low-speed condition and high lift configurations, the advance of the stall angle of attack causes the aircraft's approach speed to be too high, it is necessary to optimize the low-speed ...
YAN Wei, XU Huiwen, LI Jinye, ZHANG Ziyang, ZHANG Meihong, ZHAO Keliang, JIAO Renshan, WANG Fei, YAN Wencheng, ZENG Weiping   +9 more
doaj   +1 more source

The Effect of Spirotive Relaxation Techniques in Reducing the Level of Osteoarthritic Pain in the Elderly: Quasi Experiment Design

NSC Nursing, 2022
Introduction: Pain is a common issue in the elderly. Osteoarthritis is often encountered in the elderly and contributes significantly to pain. Pain complaints involve multifactorial and often face many hindrances in the management.
Abbasiah, Monalisa, Yunike, Mohd Syukri, Dewi Masyitah   +4 more
doaj   +1 more source

Designing experience

Future Hospital Journal, 2015
The report of the Future Hospital Commission of the Royal College of Physicians acknowledges that the principal challenge for health care organisations and professionals responsible for delivering medical services is to accept the fundamental requirement that patients must be treated with compassion, kindness and respect while having their physical and
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Tidy dataset of the experimental design of the optimization of the alkali degumming process of Bombyx mori silk

Data in Brief, 2021
Silk fibroin is the structural fiber of the silk filament and it is usually separated from the external protein, named sericine, by a chemical process called degumming.
Alessio Bucciarelli, Gabriele Greco, Ilaria Corridori, Antonella Motta, Nicola M. Pugno   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source