Results 51 to 60 of about 1,282,652 (268)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Surface Response Methodology-Based Mixture Design to Study the Influence of Polyol Blend Composition on Polyurethanes’ Properties

open access: yesMolecules, 2018
Polyurethanes are materials with a strong structure-property relationship. The goal of this research was to study the effect of a polyol blend composition of polyurethanes on its properties using a mixture design and setting mathematic models for each ...
Said Arévalo-Alquichire   +3 more
doaj   +1 more source

Formulation and Evaluation of Multidose Propofol Nanoemulsion Using Statistically Designed Experiments

open access: yesActa Chimica Slovenica, 2020
Despite of the clinical, scientific, and commercial development, many patients complain about pain on the intravenous injection of propofol. Present work was undertaken to develop a stable multi-dose propofol nano-emulsion using 32 full factorial design ...
Sidhartha Sankar Hota   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Studio delle prestazioni di giunzioni incollate ibride [PDF]

open access: yesFracture and Structural Integrity, 2011
Le giunzioni ibride sono giunzioni in cui coesistono due differenti tipologie di giunzione, di cui una è l’incollaggio. L’articolo mostra i risultati di una campagna sperimentale volta a caratterizzare le prestazioni di giunti incollati ibridi in ...
F.Moroni
doaj  

The outline of the expert system for the design of experiment

open access: yesProduction Engineering Archives, 2018
The design of experiment (DoE) is a methodology originated from early 1920s when Fisher’s papers created the analysis of variance and first known experimental designs: latin squares.
Dwornicka Renata, Pietraszek Jacek
doaj   +1 more source

Optimal Designs to Develop and Support an Experimental Strategy on Innovation of Thermoforming Production Process

open access: yesStatistica, 2017
The experimental strategy developed thanks to the DOE methodology enhance innovation capability in the field of thermoforming production processes for active packaging. It is composed of three phases: i) material characterization, ii) production in pilot
Fabrizio Ronchi   +6 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Degrees of Sulfonation: Mapping the Reactivity Landscape of Acridine and Acridone

open access: yesOrganics
Although sulfonated acridines and acridones are valuable scaffolds in diagnostics and materials science, to our best knowledge, there is no comprehensive study that addresses how the degree of sulfonation depends on reaction parameters. To fill this gap,
Péter Kisfaludi   +3 more
doaj   +1 more source

The Response Surface Methodology revisited – comparison of analytical and non-parametric approaches

open access: yesProduction Engineering Archives, 2018
Since G.E.P. Box introduced central composite designs in early fifties of 20th century, the classic design of experiments (DoE) utilizes response surface models (RSM), however usually limited to the simple form of low-degree polynomials.
Osocha Przemysław, Podgórski Jordan
doaj   +1 more source

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