Results 91 to 100 of about 4,561,954 (333)

Conceptual Design of Temperature-Controlled Fueled-Salt Irradiation Experiment to Support Demonstration of Advanced Nuclear Reactors [PDF]

, 2021
Abdalla Abou Jaoude, James Chandler, Gregory M Core, Kim B Davies, Calvin Myer Downey, William Phillips, Chuting Tan, Stacey M Wilson   +7 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Trend-resistant design of experiments under budget constraints. [PDF]

When experiments are to be performed in a time sequence, the observed responses are affected by a time trend. The construction of trend-resistant run orders is extensively described in the literature.
Tack, Lieven, Vandebroek, Martina
core  

Skúšanie opakovanej presnosti polohovania plazmovej rezacej hlavy [PDF]

, 2005
Článok stručne opisuje experimentov zameraných na overenie vybraných technologických parametrov plazmového rezacieho stroja. Konštrukčné riešenie tohto stroja predstavuje komplexnú kinematickú štruktúru s deviatimi stupňami voľnosti.
Gros, Peter, Halaj, Martin, Kureková, Eva   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Review on accelerated life testing plan to develop predictive reliability models for electronic components based on design‐of‐experiments [PDF]

, 2023
Fatima‐Ezahra Indmeskine, Laurent Saintis, Abdessamad Kobi   +2 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Optimizing chemically stable chloramphenicol in-situ gel formulations using poloxamer 407 and HPMC through full-factorial design

Scientific Reports
The primary goal was to enhance the stability and bioavailability of chloramphenicol for ophthalmic use without compromising patient comfort, such as causing blurry vision.
Insan Sunan Kurniawansyah, Taofik Rusdiana, Insi Farisa Desy Arya, Handrian Ramoko, Habibah A. Wahab   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Design of Experiments for Factor Hierarchization in Complex Structure Modelling

Advanced Electromagnetics, 2013
Modelling the power-grid network is of fundamental interest to analyse the conducted propagation of unintentional and intentional electromagnetic interferences. The propagation is indeed highly influenced by the channel behaviour.
C. Kasmi, M. Hélier, M. Darces, E. Prouff   +3 more
doaj   +1 more source