Results 51 to 60 of about 4,561,954 (333)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

A calculation model for liquid-liquid extraction of protactinium by 2,6-dimethyl-4-heptanol

Nukleonika, 2015
Reprocessing of spent nuclear fuel usually employs the solvent extraction technique to recover fissile material, isolate other valuable radionuclides, recover precious metals, and remove contaminants.
Knight Andrew W., Eitrheim Eric S., Nelson Andrew W., Schultz Michael K.   +3 more
doaj   +1 more source

R Package OBsMD for Follow-Up Designs in an Objective Bayesian Framework

Journal of Statistical Software, 2020
Fractional factorial experiments often produce ambiguous results due to confounding among the factors; as a consequence more than one model is consistent with the data. Thus, the practical problem is how to choose additional runs in order to discriminate
Laura Deldossi, Marta Nai Ruscone
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mixture Design of Experiments for the Optimization of Carbon Source for Promoting Undecylprodigiosin and Actinorhodin Production

Journal of Pure and Applied Microbiology, 2018
In this work, a mixture design was used to investigate the influence of ten carbon sources on the production of two pigments, undecylprodigiosin and actinorhodin, from Streptomyces coelicolor.
Khalid Jaber Kadhum Lut
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

QbD Based Media Development for the Production of Fab Fragments in E. coli

Bioengineering, 2019
Ranibizumab is a biotherapeutic Fab fragment used for the treatment of age-related macular degeneration and macular oedema. It is currently expressed in the gram-negative bacterium, Escherichia coli.
Deepak Kumar, Jyoti Batra, Claire Komives, Anurag S. Rathore   +3 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A Comparative Study of Alkaline Hydrolysis of Ethyl Acetate Using Design of Experiments [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2013
Alkaline hydrolysis of ethyl acetate is essentially an irreversible and second order reaction. Industrial importance of the reaction product, sodium acetate, necessitate for process improvement in terms of maximum conversion and economical usage of raw ...
Afzal Ahmad, Muhammad Imran Ahmad, Muhammad Younas, Hayat Khan, Mansoor ul Hassan Shah   +4 more
doaj  

Interaction Design: Foundations, Experiments [PDF]

, 2006
Interaction Design: Foundations, Experiments is the result of a series of projects, experiments and curricula aimed at investigating the foundations of interaction design in particular and design research in general.
Hallnäs, Lars, Redström, Johan
core   +1 more source