Results 51 to 60 of about 4,507,524 (283)

Aspects and Implementation of Pharmaceutical Quality by Design from Conceptual Frameworks to Industrial Applications

Pharmaceutics
Background/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies.
Shiwei Yang, Xingming Hu, Jinmiao Zhu, Bin Zheng, Wenjie Bi, Xiaohong Wang, Jialing Wu, Zimeng Mi, Yifei Wu   +8 more
doaj   +1 more source

Human Perception Measures for Product Design and Development—A Tutorial to Measurement Methods and Analysis

Multimodal Technologies and Interaction, 2017
This tutorial describes the necessary steps for designing and conducting a perception experiment in order to obtain design parameters for human–machine interactions.
Christian Hatzfeld, Manuel Kühner, Stefan Söllner, Tran Quoc Khanh, Mario Kupnik   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

On the design of experiments to study extreme field limits

, 2012
We propose experiments on the collision of high intensity electromagnetic pulses with electron bunches and on the collision of multiple electromagnetic pulses for studying extreme field limits in the nonlinear interaction of electromagnetic waves.
Bulanov, S. S., Bulanov, S. V., Chen, M., Chen, P., Esarey, E., Esirkepov, T. Zh., Kando, M., Koga, J. K., Korn, G., Leemans, W. P., Mur, V. D., Narozhny, N. B., Popov, V. S., Schroeder, C. B., Thomas, A. G. R., Zhidkov, A. G.   +15 more
core   +1 more source

TEACHING SOFTWARE FOR DESIGNING OF EXPERIMENTS (DOE) IN WOODWORKING PROCESSES [PDF]

Pro Ligno, 2015
This paper presents a teaching software that allows students and researchers to understand how passive and active experiments can be made, without making real experiments.
Wilhelm LAURENZI
doaj  

Optimization of the Tensile Properties of Polymeric Matrix Composites Reinforced with Magnetite Particles by Experimental Design

TecnoLógicas, 2020
A full-factorial 33 experiment was used in this study to determine the optimal values of the tensile properties of three composite materials manufactured based on three polymeric resins: Derakane Momentum epoxy vinyl ester based on bisphenol-A (DM-411 ...
Luis Ángel Lara-González, Wilmar Guillermo-Rodríguez, Yaneth Pineda-Triana, Gabriel Peña-Rodríguez, Hugo Felipe Salazar   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Optimal design of dilution experiments under volume constraints [PDF]

, 2013
The paper develops methods to construct a one-stage optimal design of dilution experiments under the total available volume constraint typical for bio-medical applications.
Zolghadr, Maryam, Zuyev, Sergei
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source