Results 71 to 80 of about 4,507,524 (283)
Training for design of experiments using a catapult [PDF]
, 2002 Design of experiments (DOE) is a powerful approach for discovering a set of process (or design) variables which are most important to the process and then determine at what levels these variables must be kept to optimize the response (or quality ...
Antony +10 more
core +1 more source
A Comparative Study of Alkaline Hydrolysis of Ethyl Acetate Using Design of Experiments [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2013 Alkaline hydrolysis of ethyl acetate is essentially an irreversible and second order reaction. Industrial importance of the reaction product, sodium acetate, necessitate for process improvement in terms of maximum conversion and economical usage of raw ...
Afzal Ahmad +4 more
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
PharmaceuticsNDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions ...
Tomas L. Roldan +7 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A Comparison of Ballistic Resistance Testing Techniques in the Department of Defense
IEEE Access, 2014 Ballistic resistance testing is conducted in the Department of Defense (DoD) to estimate the probability that a projectile will perforate the armor of a system under test.
Thomas H. Johnson +3 more
doaj +1 more source
Analysis of Quenching Parameters in AISI 4340 Steel by Using Design of Experiments [PDF]
Materials Research, 2018 This paper aims to investigate the effects of quenching parameters (temperature and time of austenitizing and cooling rate) on the microstructure, hardness and distortion of AISI 4340 steel by Design of Experiments (DoE). The factorial design was used to
Marlon Muniz Nunes +3 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Exemplary Design Research [PDF]
, 2006 In this paper, we will look at what role a research program and an interventionist research strategy based on design experiments may play for the advancement of knowledge relevant to design and designers.
Binder, Thomas, Redström, Johan
core +1 more source