Results 81 to 90 of about 4,507,524 (283)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Kernelized design of experiments [PDF]
This paper describes an approach for selecting instances in regression problems in the cases where observations x are readily available, but obtaining labels y is hard.
Rüping, Stefan, Weihs, Claus
core
Discovery Learning Experiments in a New Machine Design Laboratory [PDF]
, 2013 A new Machine Design Laboratory at Marquette University has been created to foster student exploration with hardware and real-world systems. The Laboratory incorporates areas for teaching and training, and has been designed to promote “hands-on” and ...
Anton, Fernando Rodriguez +1 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Optimal Foldover Plans for Resolution IV Designs with 17 to 21 Factors
MathematicsThis paper provides an identification of optimal foldover plans for two-level fractional factorial designs involving 17 to 21 factors, thereby augmenting the repertoire of available optimal foldover plans for resolution IV designs.
Hazael Zarco-Murillo +5 more
doaj +1 more source
R Package DoE.base for Factorial Experiments
Journal of Statistical Software, 2018 The R package DoE.base can be used for creating full factorial designs and general factorial experiments based on orthogonal arrays. Besides design creation, some analysis functionality is also available, particularly (augmented) half-normal effects ...
Ulrike Grömping
doaj +1 more source