Results 11 to 20 of about 17,265,464 (329)

Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Kv1.5 potassium channel, encoded by KCNA5, is a promising target for the treatment of atrial fibrillation, one of the common arrhythmia. A new series of arylmethylpiperidines derivatives based on DDO-02001 were synthesised and evaluated for their ability
Lingyue Zhao, Qian Yang, Yiqun Tang, Qidong You, Xiaoke Guo   +4 more
doaj   +1 more source

Optimal Technology Design

SSRN Electronic Journal, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Garrett, Daniel, Georgiadis, George, Smolin, Alex, Szentes, Balazs   +3 more
openaire   +5 more sources

Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis

Antioxidants, 2023
Ulcerative colitis (UC) is an idiopathic inflammatory disease of unknown etiology possibly associated with intestinal inflammation and oxidative stress.
Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You, Zhengyu Jiang, Xiaoke Guo   +8 more
doaj   +1 more source

Data driven analysis of social capital in Farmer Producer Companies

Heliyon, 2023
The Farmer Producer Company (FPC), a subset of the Farmer Producer Organization (FPO), is an important institutional form designed to organize farmer groups towards better coordinated farming and marketing.
Aishwarya Jayaraman, Palaniappan Ramu, Sudhir Chella Rajan, Sidhant PravinKumar Thole   +3 more
doaj   +1 more source

Optimal Crowdfunding Design [PDF]

SSRN Electronic Journal, 2014
Trabajo presentado en la 43rd EARIE (European Association for Research in Industrial Economics) Annual Conference, organizada por la Nova School of Business and Economics (Nova SBE) en Lisboa del 26 al 28 de agosto de 2016 We characterize optimal reward-based crowdfunding where production is contingent on an aggregate funding threshold.
Matthew Ellman, Sjaak Hurkens
openaire   +8 more sources

Machine Learning for Design Optimization of Electromagnetic Devices: Recent Developments and Future Directions

Applied Sciences, 2021
This paper reviews the recent developments of design optimization methods for electromagnetic devices, with a focus on machine learning methods. First, the recent advances in multi-objective, multidisciplinary, multilevel, topology, fuzzy, and robust ...
Yanbin Li, G. Lei, G. Bramerdorfer, S. Peng, Xiaodong Sun, Jianguo Zhu   +5 more
semanticscholar   +1 more source

Advanced RF and Microwave Design Optimization: A Journey and a Vision of Future Trends

IEEE Journal of Microwaves, 2021
In this paper, we outline the historical evolution of RF and microwave design optimization and envisage imminent and future challenges that will be addressed by the next generation of optimization developments.
J. Rayas-Sánchez, S. Koziel, J. Bandler
semanticscholar   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Antioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu, Qiuyue Zhang, Yuqi Guo, Hengheng Zhang, Xiaoke Guo, Qidong You, Lei Wang   +6 more
doaj   +1 more source

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

Molecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li, Jing-jing Li, Ni Zhao, Ying Ma, Bin Di   +4 more
doaj   +1 more source

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang, Yu Xia, Chunqiu Yu, Huijie Du, Jinchang Liu, Hui Li, Shihui Huang, Qihua Zhu, Yungen Xu, Yi Zou   +9 more
doaj   +1 more source