Results 11 to 20 of about 555,083 (264)

Optimal Technology Design

SSRN Electronic Journal, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Garrett, Daniel, Georgiadis, George, Smolin, Alex, Szentes, Balazs   +3 more
openaire   +5 more sources

Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis

Antioxidants, 2023
Ulcerative colitis (UC) is an idiopathic inflammatory disease of unknown etiology possibly associated with intestinal inflammation and oxidative stress.
Xian Zhang, Keni Cui, Xiaolu Wang, Yuanyuan Tong, Chihong Liu, Yuechao Zhu, Qidong You, Zhengyu Jiang, Xiaoke Guo   +8 more
doaj   +1 more source

Optimal Crowdfunding Design [PDF]

SSRN Electronic Journal, 2014
Trabajo presentado en la 43rd EARIE (European Association for Research in Industrial Economics) Annual Conference, organizada por la Nova School of Business and Economics (Nova SBE) en Lisboa del 26 al 28 de agosto de 2016 We characterize optimal reward-based crowdfunding where production is contingent on an aggregate funding threshold.
Matthew Ellman, Sjaak Hurkens
openaire   +8 more sources

Data driven analysis of social capital in Farmer Producer Companies

Heliyon, 2023
The Farmer Producer Company (FPC), a subset of the Farmer Producer Organization (FPO), is an important institutional form designed to organize farmer groups towards better coordinated farming and marketing.
Aishwarya Jayaraman, Palaniappan Ramu, Sudhir Chella Rajan, Sidhant PravinKumar Thole   +3 more
doaj   +1 more source

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

Molecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li, Jing-jing Li, Ni Zhao, Ying Ma, Bin Di   +4 more
doaj   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Antioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu, Qiuyue Zhang, Yuqi Guo, Hengheng Zhang, Xiaoke Guo, Qidong You, Lei Wang   +6 more
doaj   +1 more source

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang, Yu Xia, Chunqiu Yu, Huijie Du, Jinchang Liu, Hui Li, Shihui Huang, Qihua Zhu, Yungen Xu, Yi Zou   +9 more
doaj   +1 more source

Optimization design in single wagon-wheel fuel grain of hybrid rocket motor

FirePhysChem, 2021
The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang, Cai Guobiao, Tian Hui, Zhu Hao, Zhang Yuanjun, Li Xintong   +5 more
doaj   +1 more source

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

Molecules, 2023
At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu, Sudan Sun, Qidong You, Lei Wang   +3 more
doaj   +1 more source

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Acta Pharmaceutica Sinica B, 2022
The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You, Zhengyu Jiang   +10 more
doaj   +1 more source