Results 21 to 30 of about 555,083 (264)

High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

Advances in Aerodynamics, 2022
Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation.
Bo-Wen Zan, Zhong-Hua Han, Chen-Zhou Xu, Ming-Qi Liu, Wen-Zheng Wang   +4 more
doaj   +1 more source

Multi-objective topology design optimization combined with robust optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2023
Topology optimization (TO), which is a design optimization technique that does not require design parameters, has been attracting attention. TO has a high degree of freedom and can obtain a novel design shape suitable for desired purposes.
Akito MARUO, Norihiko ITANI, Ayano HASOME, Takashi YAMAZAKI, Hajime IGARASHI   +4 more
doaj   +1 more source

Optimal Experimental Designs

The Annals of Mathematical Statistics, 1966
Abstract : This paper presents a number of results concerning the theory of the optimal design of experiments initiated and principal developed by Elfving, Kiefer and Wolfowitz. The paper contains approximately half expository and half new material. The proofs are mostly new and presented in a unified manner.
Karlin, Samuel, Studden, William J.
openaire   +2 more sources

Optimal experimental design for optimal process design: A trilevel optimization formulation

AIChE Journal, 2019
AbstractTypical optimal experimental design (OED) methods aim at minimizing the covariance matrix of the estimated parameters regardless of the intended application of the model that is being estimated. This can unnecessarily increase the experimental costs.
Walz, Olga, Djelassi, Hatim, Mitsos, Alexander   +2 more
openaire   +3 more sources

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

Molecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang   +4 more
doaj   +1 more source

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

European Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He, Ke Wang, Haojie Che, Huifang Wang, Kan Yang, Guiming Zhang, Jingchun Yao, Jinxin Wang   +7 more
doaj   +1 more source

Flow structures and wall parameters on rotating riblet disks and their effects on drag reduction

Alexandria Engineering Journal, 2022
The demand of energy saving and loss mitigation in modern industry gives rise to drag reduction techniques such as micro groove/riblet ever since the last century.
Tong Liang, Yang Xu, Jiawen Li, Guobiao Cai   +3 more
doaj   +1 more source

BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

Scientific Reports, 2021
Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors.
Yu Li, Yuantao Wang, Wanpeng Zhang, Xinchen Wang, Lu Chen, Shuping Wang   +5 more
doaj   +1 more source

Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij, Catia Olianti, Herve Brisse, Pier Luigi Di Paolo, Maria Garganese, Tejas Kapadia, Jurgen Schaefer, Hugh Wallace, Simon Wan, Bart de Keizer, Irmina Sefic Pasic, Julian Rogasch   +11 more
wiley   +1 more source

Recognition and Positioning of Fresh Tea Buds Using YOLOv4-lighted + ICBAM Model and RGB-D Sensing

Agriculture, 2023
To overcome the low recognition accuracy, slow speed, and difficulty in locating the picking points of tea buds, this paper is concerned with the development of a deep learning method, based on the You Only Look Once Version 4 (YOLOv4) object detection ...
Shudan Guo, Seung-Chul Yoon, Lei Li, Wei Wang, Hong Zhuang, Chaojie Wei, Yang Liu, Yuwen Li   +7 more
doaj   +1 more source