Results 71 to 80 of about 17,265,464 (329)

Advances in the structures, mechanisms and targeting of molecular chaperones

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +1 more source

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Redox Biology, 2019
The Keap1-Nrf2-ARE pathway regulates the constitutive and inducible transcription of various genes that encode detoxification enzymes, antioxidant proteins and anti-inflammatory proteins and has pivotal roles in the defence against cellular oxidative ...
Meng-Chen Lu, Jing Zhao, Yu-Ting Liu, Tian Liu, Meng-Min Tao, Qi-Dong You, Zheng-Yu Jiang   +6 more
doaj   +1 more source

Matrix-Monotonic Optimization for MIMO Systems [PDF]

, 2014
For MIMO systems, due to the deployment of multiple antennas at both the transmitter and the receiver, the design variables e.g., precoders, equalizers, training sequences, etc. are usually matrices.
Ma, Shaodan, Xing, Chengwen, Zhou, Yiqing   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Mathematical Modeling and Multi-Criteria Optimization of Design Parameters for the Gyratory Crusher [PDF]

, 2023
V. P. Kondrakhin, Nikita V. Martyushev, Roman V. Klyuev, Svetlana N. Sorokova, Egor A. Efremenkov, Denis V. Valuev, Mengxu Qi   +6 more
openalex   +1 more source

A hybrid multiagent approach for global trajectory optimization [PDF]

, 2008
In this paper we consider a global optimization method for space trajectory design problems. The method, which actually aims at finding not only the global minimizer but a whole set of low-lying local minimizers(corresponding to a set of different design
A. Torn, C.D. Perttunen, C.P. Stephens, D.R. Jones, E. Elbeltagi, E.R. Dam, G. Rauwolf, J.W. Hartmann, Marco Locatelli, Massimiliano Vasile, P. Gurfil, P. Pascale De, P.J. Gage, R. Horst, R. Storn, W. Huyer   +15 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

Proceedings, 2019
Antibiotic resistance is one of the biggest threats to humankind [1,2]. [...]
Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch   +3 more
doaj   +1 more source

A constrained multi-objective surrogate-based optimization algorithm [PDF]

, 2014
Surrogate models or metamodels are widely used in the realm of engineering for design optimization to minimize the number of computationally expensive simulations.
Couckuyt, Ivo, Dhaene, Tom, Ferranti, Francesco, Singh, Prashant   +3 more
core   +1 more source