Results 171 to 180 of about 31,965,129 (228)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

['Theorizing in Design Research', 'Theorizing in Design Research', 'Theorizing in Design Research', 'Theorizing in Design Research']

Avances de Investigación en Educación Matemática, 2019
openaire   +1 more source

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Virtual Environments for Design Research: Lessons Learned from use of Fully Immersive Virtual Reality in Interior Design Research

Journal of Interior Design, 2020
What are the current challenges, effectiveness, and future research opportunities for using fully immersive virtual environments (FIVEs) for design research? To answer these questions, we conducted a systematic review to assess peer–reviewed experimental
S. Kalantari, Jun Rong Jeffrey Neo
semanticscholar   +1 more source

Research Design in Clinical Psychology

, 2021
Research Design in Clinical Psychology helps students to achieve a thorough understanding of the entire research process – developing the idea, selecting methods, analyzing the results, and preparing the written scientific report.
A. Kazdin
semanticscholar   +1 more source

Design research in education. A practical guide for early career researchers

Mathematical Thinking and Learning, 2019
As befitting a treatise on design research, this volume steers a course between the pragmatics of formulating and conducting design research, on the one hand, and on the other, the ensemble of theo...
R. Lehrer
semanticscholar   +1 more source