Results 31 to 40 of about 5,060,080 (299)

Method to Investigate Multi-Axis Release Action of Ski Safety Bindings: A New Approach for Testing in Research and Development

Frontiers in Sports and Active Living, 2021
The authors developed and elaborated on a new method to release ski bindings by utilizing an industrial robot to simulate release movement showing a spatial repeatability of ± 0.06 mm.
Florian Nimmervoll, Roland Eckerstorfer, Johannes Braumann, Alexander Petutschnigg, Bruno Sternad   +4 more
doaj   +1 more source

Uncovering terra incognita in the AHD design space: A review of affective haptic devices

Frontiers in Computer Science, 2022
Affective haptic devices (AHDs) have been developed with the aim of communicating touch acts, symbolic messages, emotions, and/or providing a sense of social awareness.
Sima Ipakchian Askari, Sima Ipakchian Askari, Antal Haans, Wijnand A. IJsselsteijn   +3 more
doaj   +1 more source

Mission-Driven Inverse Design of Blended Wing Body Aircraft with Machine Learning

Aerospace
The intent of this work was to investigate the feasibility of developing machine learning models for calculating values of airplane configuration design variables when provided time-series, mission-informed performance data.
Rohan S. Sharma, Serhat Hosder
doaj   +1 more source

Formulation Considerations for Autologous T Cell Drug Products

Pharmaceutics, 2021
Genetically modified autologous T cells have become an established immunotherapy in the fight against cancer. The manufacture of chimeric antigen receptor (CAR) and αβ-T cell receptor (TCR) transduced T cells poses unique challenges, including the ...
Christopher F. van der Walle, Sonya Godbert, Gabriele Saito, Zein Azhari   +3 more
doaj   +1 more source

Quantifying "Cliffs" in Design Space

, 2014
This paper studies the regions of parameter space of engineering design in which performance is sensitive to design parameters. Some of these parameters (for example, the dimensions and compositions of components) constitute the design, but others are ...
Katz, J. I.
core   +1 more source

An atlas of gene regulatory networks reveals multiple three‐gene mechanisms for interpreting morphogen gradients

Molecular Systems Biology, 2010
The interpretation of morphogen gradients is a pivotal concept in developmental biology, and several mechanisms have been proposed to explain how gene regulatory networks (GRNs) achieve concentration‐dependent responses.
James Cotterell, James Sharpe
doaj   +1 more source

Development of a Quantitative Chromatographic Fingerprint Analysis Method for Sugar Components of Xiaochaihu Capsules Based on Quality by Design Concept

Separations, 2022
Background: Xiaochaihu capsule is composed of seven traditional Chinese medicines. The pharmacopoeia only focuses on the quantitative detection of baicalin, which cannot fully reflect the quality of the preparation. Some medium polar components were used
Jing Lan, Gelin Wu, Linlin Wu, Haibin Qu, Ping Gong, Yongjian Xie, Peng Zhou, Xingchu Gong   +7 more
doaj   +1 more source

Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator

Pharmaceuticals
This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry.
Miquel Romero-Obon, Virginia Sancho-Ochoa, Khadija Rouaz-El-Hajoui, Pilar Pérez-Lozano, Marc Suñé-Pou, Josep María Suñé-Negre, Encarna García-Montoya   +6 more
doaj   +1 more source

Application of the concept of design space in method development for the determination of contaminants in soil [PDF]

Proceedings of the Estonian Academy of Sciences
The analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls is an important topic in environmental analysis, and several analysis procedures have already been proposed.
Jelena Jurjeva, Mihkel Koel
doaj   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source